The main purpose of this gel formulation of Guava leaves, Argemone Mexicana, Turmeric and Elaichi flavor was to relieve pain and discomfort due to oral ulcers. As we know there are different types of sores in the mouth that cause inflammation and pain. The most common oral ulcers are Local trauma & Aphthous Stomatitis. Now many over-the-counter medications are essential to staying in primary health care because of the positive response and the most effective treatment with the least amount of side effects. Herbal medicines are still the backbone of almost 75-80% of the world's population, especially in developing countries, in primary health care due to better adherence to the human body, cultural acceptance and less side effects. They are found mainly in tropical and subtropical regions of India, the Americas and Africa, where they occur in various countries. The gel contains the main ingredients Guava Leaves Powder, A. Mexicana, Elaichi & Carbopol 934 as a gelling agent & and Propylene glycol as a co-solvent. Another ingredient Haldi acts as an antiseptic. The formulated gel was tested for different parameters such as physicochemical parameters (pH, viscosity, distribution ability, etc.), inhibition area, etc. The gel is homogeneous mixture that shows the pH 6.8. This herbal gel was stable at room temperature protected from any germs and thus safe for use on mouth sores.

The goal of the Novel Drug Delivery System is to deliver a therapeutic dose of drug to an appropriate place within the body quickly so that the desired drug concentration can be maintained. Over a set treatment period, the drug-delivery system should supply the medicine at a rate controlled by the body's requirements. A transdermal patch is a medicated adhesive patch that is applied to the skin to deliver a specific amount of medication into the bloodstream through the skin. This generally aids in the recovery of a damaged bodily part. The patch provides a controlled release of medication into the patient, usually through a porous membrane covering a reservoir of medication or through thermoregulation melting thin layers of drug incorporated in the adhesive, which is a benefit of transdermal drug delivery over other types of medication delivery such as oral, topical, intravenous, intramuscular, and so on. As a result of persistent experimentation with nature, man must have known the therapeutic potential of neem since past. When used both internally and externally, it is beneficial to the skin. It cleanses the blood and treats acne, pimples, boils, and other skin problems. The flavour of neem is bitter. However, it is this bitterness that is responsible for the tree's therapeutic efficiency. Transdermal patches are presently available in a wide range of therapeutics.