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Wereport a 38-year-old womanwith a mild form of hyperglycinemia complicated with optic nerve atrophy and convulsion. She was normal at birth and showed normal mental and physical development. After the age of 13, her visual acuity rapidly decreased. At the age of 33, she had numerous episodes of tonic seizures lasting for 1-2 minutes. She had optic atrophy, but no intellectual impairment. Glycine levels of the plasma, urine and cerebrospinal fluid were markedly increased, but the CSF/serum glycine ratio was slightly higher than the normal range. Although there is one case of retinal impairment of hyperglycinemia in the literature, this is the first report of blindness with hyperglycinemia in a 38-year-old woman. (Internal Medicine 32: 641-642, 1993)

The enthalpies of formation of hydrogen bonding complexes AH°were obtained by precision calorimetry for hydrogen fluoride (HF)-furan, HF-tetrahydrofuran (THF), HF-2,5-dimethylfuran (2,5-di-MeF), and HF-2,5-dimethyltetrahydrofuran (2,5-di-MeTHF). The frequency shift Afhf of H-F stretching vibration due to hydrogen bond formation and the equilibrium constant of complex formation were also obtained by infrared spectral measurement and were used to evaluate free energy and entropy of complex formation. The Badger-Bauer relation was found to exist between AH°and Afhf• The AH0 difference between HF-furan (4.8 kcal mol-1) and HF-2,5-di-MeF (6.74 kcal mol-1) was fairly large, while that between HF-THF (7.36 kcal mol-1) and HF-2,5-di-MeTHF (7.41 kcal mol-1) was almost negligible. Ab initio MO calculations were carried out for HF-furan and HF-THF complexes. The calculated equilibrium geometry and hydrogen bonding energy were in good agreement with the trend of experiments. Component analyses showed that the main difference between the two complexes was in the electrostatic interaction and that the presence of conjugated electrons changed only the polarization interaction, resulting in a dipole enhancement.

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Visual depth perception in 100 patients with cerebrovascular disease was evaluated using the Titumus stereotest. Twelve patients showed depth perception impairment. CT scans revealed that the lesion was located on the right hemisphere in 6 patients and on the left hemisphere in 3 patients, and that the remaining 3 patients had multiple infarctions. lnI SPECT was performed in 7 patients with moderate to severe depth perception impairment, of whom 6 patients showed a reduced blood flow in the posterior half of both the right and left cerebral hemispheres. Moderate to severe impairment of depth perception was more frequently observed in patients with a lesion in the right hemisphere or in the posterior half of either hemisphere.