Prediction for canceled booking hotels is an important part of hotel revenue management systems in the modern era. Because the predicted result can be used for the optimization of hotel performance. The application of machine learning will be very helpful for predicting canceled booking hotels because machine learning can process complex data. In this research, the proposed methods are Artificial Neural Network (ANN) and Logistic Regression. Later it will be done five times experiments with hyperparameter tuning to see which method is the most optimal to do prediction canceled booking hotel. From five times experiments, experiments number five (logistic regression with GridSearchCV) is the most optimal for predicting canceled booking hotels, with 79.77% accuracy, 85.86% precision, and 55.07% recall.