The increasing number of people with diabetes has an impact on the global burden of diabetes mellitus (DM) becoming a major public health priority, placing unsustainable demands on individuals, their guardians, economies, health systems and society. The increase in the number of DM is influenced by the increase in the prevalence of obesity and unhealthy behaviors including poor diet and physical activity. In reducing the morbidity rate, there needs to be an effort to control blood glucose levels, one of which is ergonomic exercise based on spiritual care. The purpose of this study was to determine the effect of ergonomic exercise based on spiritual care on blood glucose in the elderly with diabetes mellitus. The design of this study used a quasi-experimental with a control group. The population of this study were all elderly people with diabetes mellitus. The sample of this study was 104 respondents, divided into 52 intervention groups and 52 control groups. This research instrument uses an observation sheet. This research was conducted in April - June 2022. The results of this study obtained an average blood glucose level in the intervention group 2.69 and in the control group 2.70 with p value = 0.957.