Aims:To determine the pattern of ocular disorders in HIV-positive patients in a tertiary ospital in Nigeria. Study Design: A cross-sectional hospital based study on confirmed HIV positive adult patients attending the HIV clinic in University of Port Harcourt Teaching Hospital. Duration of Study: November and December 2011. Methodology: Consecutive patients within the inclusion criteria were recruited until the required sample size was met. The visual acuity was tested using the Snellen's chart and the illiterate Echart. Ocular examination of the adnexial and anterior segments were done using a pen torch and a slit lamp biomicroscope. Fundoscopy was done using a direct and indirect ophthalmoscope as well as with a 90D lens. Other information such as CD4 count and HIV serotype were retrieved from the patient's case notes. The data was analysed using EPI-info version 7.0. Statistical methods such as the frequency and chi-square were used to test the significance of association. Level of significance was drawn at P<0.05. Results: A total of 411 patients were enrolled in this study. The age range was between 18-69 years with a mean age of 36.9 years. There was a female preponderance with a male to female ratio of 1:2. Ocular disorders were seen in 37.1% of patients studied. The commonest manifestation Arowolo et al.; IJTDH, 39(3): 1-9, 2019; Article no.IJTDH.53024 2 was the ocular adnexial manifestation and conjunctival microvasculopathy ranked highest (15.6%) in this group. Herpes zoster ophthalmicus was seen in 5 (1.2%) patients, presumed squamous cell carcinoma in 12(2.9%) and Kaposi sarcoma in 3(0.7%). Chorioretinitis was found in 12(2.9%), retinal microvasculopathy in 19(4.6%) and maculopathy in 15(3.6%). There was no case of CMV retinitis. Conclusion: Ocular findings seen in HIV-positive patients were mostly adnexial and occurred in 37% of the study population. Original Research Article