The oil and gas industry struggles to prevent formation of hydrates in pipeline by spending substantial amount of dollars. Hydrates are ice-like crystalline compounds that are composed of water and gas in which the gas molecules are trapped in water cavities. The hydrate formation is favorable at elevated pressure and reduced temperature and can be determined through experiment. However, the cost involved to determine early hydrate formation using experiment is driving researchers to seek for robust prediction methods using statistical and analytical methods. Main aim of the present study is to investigate applicability of radial basis function networks and support vector machines to hydrate formation conditions prediction. The data needed for modeling was taken from well-established literature. Performance of the models was assessed based on MSE, MAE, MAPE, MSPE, and Modified Pearson’s Correlation Coefficient. Data-based models enable the oil industry to predict the conditions leading to hydrate formation hence preventing clogging of the pipeline and high pressure buildup that could lead to sudden burst at the connections.