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ABSTRACT:The s ynt hetic organic az o d ye s unset yellow is a widel y us ed in f ood prod ucts, such as drinks, yog hurts , ic e cream, and sweets . T he soluti ons of t his c ol oured d ye are not s table in s unlight or in dark, partic ularl y w hen common f ood acids (e.g. citric acid and asc orbic acid) are pres ent. T he d egraded products from s uns et yellow are s ulphanilic acid and the s odium sal t of 2 -naphthalenesulphonic acid -5-amino-6-hydroxyl. T hese products f urther undergo deami nation up on prolonged s unlight irradiation to prod uce benz ene sul fonic acid sodium s alt (B SA -N a) and ammonia as final products . T he p urpose of t his st ud y w as t o ass ess t he t oxicit y BS ANa on the liv er and brain of m ale growi ng Sprague-D awley rats. O xidative str ess and relat ed gene transcription of the antioxidant enz ym es hav e been ass essed in m ale growing rats supplement ed the different concentration of B SA-N a (34. 8, 69.4, and 153. 6 µg/kg. B.W .) through t he experiment al period. T he results s howed that t hese concentrations of B SA-N a c aused significant increase i n the activit y of t he antioxidant enz ym es, t ot al sup eroxide dismut ase (SOD), cat alas e (CAT), glutat hione S -tr ans fer ase (GST), glut at hione reductase (GR), xanthi ne oxidas e (X O) and lipid peroxidati on lev el in liver and brain of growing male rats as compared wit h t heir c ontrol. A significant retardati o n in growth rat e w as observ ed in rat supplem ent ed B SA-N a. In addition, t hese concentrations of BS A-Na signific antl y caused i ncreas e i n C u/Z n s uper oxide dismutas e (Cu/Zn SOD) g ene tr ans cription. The data clearl y d emonstr ate t hat B SA -Na can res ult i n oxidativ e s tress in bot h liv er and brai n of t he growing rat. KEY WORDS:O xidative stres s, s uns et yellow , benzene sulfonic acid sodium sal t, liver, brain, Cu/Z n S OD. CORRESP ONDENCE:Mo ham ed A b d el m onei m M. H eg az i

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