This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from a copolymer of poly(methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)) with different monomer ratios have been synthesized and used as a drug carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite was also synthesized using an in-situ microemulsion polymerization technique and used as a 5-FU carrier. Different techniques have characterized these groundbreaking drug delivery systems such as FT-IR, XRD, TEM, TGA, zeta potential, and a particle size analyzer. The effects of monomer feed composition, 5-FU content, and MWCNTs content on morphological and structural properties, in-vitro 5-FU release, and entrapment efficiency (EE%) have been studied. It was noted that the inclusion of MWCNTs in the 5-FU-loaded polymer increases the thermal stability and raises the entrapment efficiency (EE%) to hit 99% at CNTs:5-FU ratio of 2:1. The anticancer drug release from the co-polymeric nanospheres depends on the HEMA ratio, 5-FU/copolymer ratio, CNT/5-FU ratio, and the pH of the medium. The optimized nanocomposite demonstrated higher anti-tumor activity against the cell lines CaCo-2, MCF-7, and HepG-2 and higher cytotoxicity against HepG-2 relative to CaCo-2 and MCF-7.

Industrial wastewater is obtained from industrial activities that include any solids that become useless during the manufacturing process. These wastes are considered as international green problems so significant solutions must be taken to confront these problems and reduce their environmental burden and effect. Removal of dyes from industrial wastes using zeolite and marine algae by adsorption technique has a lot of advantages as the zero cost, obtainability, high effectiveness, and ecological alternative source. Dyes adsorption onto zeolite and marine algae surfaces is a complicated method that affected by numerous factors like contact time, initial dye concentration, solution pH, catalyst weight and temperature. In this review, we present definition of marine algae and their classification, definition of Zeolite , industrial wastewater and their effect on the eco system, water treatment methods which include chemical, biological, Combinatorial method, nanotechnology-based and physical methods, uses of algae and natural zeolite in wastewater treatment and finally we discuss the factors that affect dyes adsorption onto zeolite and marine algae surfaces, such as contact time, temperature, solution pH and catalyst dose. The principal conclusions of this review are that the dye removal% is high in the early time of the adsorption operation but it reduces still it reaches equilibrium, Temperature negatively affects the dye adsorption method, there is a specific pH value for each catalyst, at which the optimum adsorption of dyes happens as well as adsorbent dose growth in general enhances catalytic activity because of the increase in total surface area and the total of active sites on catalyst surface. For optimizing the conditions for dye adsorption onto zeolite and marine algae, the factors that affect dye adsorption onto zeolite and marine algae surfaces should be known.

This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from a copolymer of poly(methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)) with different monomer ratios have been synthesized and used as a drug carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite was also synthesized using an in-situ microemulsion polymerization technique and used as a 5-FU carrier. Different techniques have characterized these ground-breaking drug delivery systems such as FT-IR, XRD, TEM, TGA, zeta potential, and a particle size analyzer. The effects of monomer feed composition, 5-FU content, and MWCNTs content on morphological and structural properties, in-vitro 5-FU release, and entrapment efficiency (EE%) have been studied. It was noted that the inclusion of MWCNTs in the 5-FU-loaded polymer increases the thermal stability and raises the entrapment efficiency (EE%) to hit 99% at CNTs:5-FU ratio of 2:1. The anticancer drug release from the co-polymeric nanospheres depends on the HEMA ratio, 5-FU/copolymer ratio, CNT/5-FU ratio, and the pH of the medium. The optimized nanocomposite demonstrated higher anti-tumor activity against the cell lines CaCo-2, MCF-7, and HepG-2 and higher cytotoxicity against HepG-2 relative to CaCo-2 and MCF-7.