The organocatalyzed aerobic oxidation of aldehydes to
acids was
reproduced from the original report. In- and ex-situ analysis of the reaction mixture as the function
of time reveals that, unlike the claim in the publication, the aerobic
oxidation of aromatic and aliphatic aldehydes leads predominantly
to the formation of peracids. The latter are transformed into the
corresponding carboxylic acids during the workup procedure. The buildup
of peracids in solution poses safety problems that should not be overlooked.
This finding has also an influence on the way new catalysts are investigated
to improve this reaction as well as on aerobic aldehyde-mediated co-oxidation.
New substituted aroylhydrazones (4a-f) were synthesized from the acid hydrazide (3) and the corresponding aldehyde or aldose. 5-Amino-4-cyano-1H-pyrazole derivatives (6a-f) were prepared by the reaction of the aroylhydrazones (4a-f) with malononitrile. The synthesized compounds were tested for antimicrobial activity against various bacteria and fungi and showed moderate to high inhibition activities. Compounds incorporating a sugar moiety as well as a pyrazolyl ring in their structure displayed the highest antimicrobial activity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.