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Subclinical hypothyroidism (SCH) is a metabolic disorder with prevalence about 4-10% in general population. This study was conducted to observe the pattern of fasting lipid profile in SCH and to correlate the components of it with thyroid stimulating hormone and free thyroxin level. This cross sectional observational study included 31 newly diagnosed cases of SCH and 17 age and BMI matched healthy control subjects with normal thyroid function test. Fasting lipid profile was recorded and compared. TSH was significantly higher in SCH compared to controls (9.09±2.79 vs 2.31±0.92 μIU/ml; p=0.001). FT4 was comparable between the groups (1.17±0.18 vs 1.28±0.20 ng/dl; p=0.938). Significantly higher level of Total cholesterol and LDL-C were observed in SCH compared to controls (TC 194.77±29.70 vs 156.59±20.45 mg/dl; p=0.042 and LDL-C 124.81±27.85 mg/dl vs 88.59±18.41mg/dl; p=0.045 respectively). Triglycerides and HDL-C were comparable between the groups (TG 134.90±80.97 vs 118.12±49.14 mg/dl; p=0.171 and HDL-C 42.87±4.83 vs 44.47±5.66; p=0.633 respectively). TSH showed significant positive correlation with TC and LDL-C (r=0.591, p<0.001 and r=0.644, p<0.001 respectively), but not with TG or HDL-C (r=0.011, p=0.943 and r=0.115, p=0.435 respectively). FT4 only showed significant negative correlation with LDL-C (r=0.302; P=0.037) but not with TC, TG or HDL-C (TC: r=0.245, P=0.093; TG: r=0.121, p=0.411 and HDL-C: r=0.108, p=0.466 respectively). SCH is associated with raised TC and LDL-C. So patients with SCH are more vulnerable to develop future adverse cardio-metabolic complications. Faridpur Med. Coll. J. 2021;16(1):17-20

Background: Despite noteworthy socio-economic development and advancement of medical science, till now tuberculosis (TB) is considered a major public health problem. Although TB is a curable disease, still millions of people suffer from TB every year and a number of them die from this infectious disease. Now a day, the prevalence and nature of tuberculosis are not in a consistent stage. We need more current information regarding this issue. Aim of the study: The aim of this study was to determine the clinical profile of tuberculosis patients. Methods: This study was a prospective, observational study which was conducted in the Department of Internal Medicine, US-Bangla Medical College, Narayanganj, Bangladesh during the period from January 2020 to December 2020. In total 73 diagnosed patients with tuberculosis, treated in this hospital were selected as the study subjects. Properly written consent was taken from all the participants before data collection. All data were processed, analyzed, and disseminated by using MS Office and SPSS version 23 as per need. Results: In this study, the majority of the participants were from the>40 years age group. One-third (34%) of participants were primary level educated whereas one-fourth (25%) were secondary level educated. The majority (56%) of the patients were found as ‘never smokers’. ‘Never drinker’ (Alcohol) was found 86%. Among the highest number of participants, pulmonary Koch’s was found which was in 42%. Among all the participants, cough and fever were found as two more frequent symptoms which were found in 96% and 86% patients respectively. As the final treatment outcome, we observed, 42% (n=31) patients were fully cured. Treatment was continued on 53% of patients and 4% (n=3) death cases were found. Conclusion: According to the findings of this study we can conclude that fever and cough are the two most frequent symptoms in tuberculosis patients. Although the death rate among TB patients is not alarming, the .........

Background: COPD is one of the most widespread noncommunicable diseases, and its incidence is on the rise in developing countries. Acute COPD exacerbation is linked to a higher financial burden on the health system, as well as a negative impact on patients’ health in terms of lost working days, functional capacity, and mortality. COPD exacerbation is characterized by a worsening of symptoms such as cough and dyspnea, as well as a considerable risk of type-II respiratory failure. An understanding of the symptoms and signs, as well as the causes linked to acute COPD exacerbation in our population, is thought to aid in the prevention of such exacerbations, reducing the burden on patients and the community. Aim: This study is meant to bring forth the clinical profile and variables related with acute exacerbation of COPD among our community, taking into account the specific symptoms preceding an exacerbation of COPD and the variety of factors associated with it in different parts of the world. This study characterizes the clinical signs and symptoms of COPD acute exacerbations, as well as investigates the involvement of a respiratory tract infection in COPD exacerbation establishing a relationship between smoking and COPD exacerbation. Method: This is a hospital-based cross-sectional observational study. The study was conducted at the Dhaka Medical College Hospital’s Department of Medicine (DMCH). A method of purposive sampling was applied. The study took place from November 2012 until June 2013. The sample size computed for this study is 75. Result: Age above 7th decade increases mortality risk by 2.32 times. Meanwhile, comorbidity, low BMI (<18.5 kg/m2), smoking and frequent acute exacerbation increases risk by 1.29 times, 1.16 times, 0.03 times and by 2.07 times respectively in patients having COPD. Conclusion: Chronic obstructive pulmonary disease (COPD) is more frequent in the 6th decade of life and is male predominant. Recovery period has been found longer in the presence of dyspnea or symptoms of a common cold at exacerbations onset, higher PaCO2 and lower pH has been found in the patients admitted in ICU. Low BMI, RTI, Smoking and Comorbidity are more frequent in patients with chronic obstructive pulmonary disease (COPD). Sir Salimullah Med Coll J 2022; 30: 161-167

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