Purpose To investigated existing articles about the impact of positive family history of cancer on increased risk of colorectal cancer in EMRO countries Method PubMed, Scopus, and Web of science are selected as our databases. Newcastle-Ottawa (NCO) Checklist is used for quality assessment. Odds Ratio with 95% confidence interval was used to compare the effect of family history of cancer in case and control group Result Finally, 27 articles are carefully selected to be in our study. Our Meta-analysis showed a significantly positive association between positive family history of ANY Cancer or CRC on increased risk of CRC (OR = 1.76; 95% CI:1.27–2.42; P = 0.001, OR = 2.21; 95% CI:1.54–3.17; P < 0.001 respectively). Subgroup analysis revealed that positive family history of ANY cancer in First-Degree significantly increased the risk of CRC (OR = 2.12; 95% CI:1.65–2.73; P < 0.001). Positive family history of CRC in First-Degree relatives is also associated with increased risk of CRC (OR = 2.19; 95% CI:1.22–3.91; P = 0.008). Conclusion Our results show the importance of screening and early identification of patients with family history. Coordinating health care facilities and encouraging people to use screening methods for early detection and therefore better treatment can reduce mortality and financial costs for general public.