A number of antitumor and other bioactive compounds were previously isolated from Vernonia amygdalina Del. This study was designed to further isolate and characterize compounds of medicinal value that may also have antitumor activity from this edible and commonly available plant. Bioassay-guided fractionation of the leaf extract of V. amygdalina (MEVA) led to the isolation and characterization of a known compound, epivernodalol for the first time in this plant. Its structure was identified by spectroscopic methods including 1 H-NMR, 13 C-NMR, MS, UV and IR spectra. In vitro growth inhibitory and cytotoxic evaluation of MEVA, its fractions and epivernodalol against HT-144 (skin melanoma) cell line was carried out by the Sulforhodamine B (SRB) assay. The results showed that epivernodalol and the dichloromethane fraction of V. amygdalina were active against HT-144 (skin melanoma) cell line. Vernonia amygdalina Del. leaf extract yielded another cytotoxic which was active against skin cancer.

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This paper presents experimental investigation for particles breakage for natural sand. The particle breakage was induced by subjecting the sample to one dimensional compression. Grain size analyses were performed before and after induced breakage. Thereafter, the sand shear strength parameters were assessed using direct shear box tests and the coefficient of permeability was assessed using constant head permeameter. Examining the obtained results revealed that the amount of breakage due to one dimensional compression was of order higher than the amount occurring during direct shear test. Peak shear strength parameters decreased with the particles breakage increasing. Moreover, dilation angle of shear strength pronouncedly decreases with the amount of particles breakage increasing. Crushing has obvious effect on the evaluated coefficient of permeability.

The compressive stress-strain behavior and other characteristics of treated fly ash based roof tiles have been studied by several experimental tests. This paper attempts to presents the results and observations of a study and comparison based on the past reported experimental data. Based on the results and observations of the comprehensive experimental study, five "control points" have been identified. The new sets of experiment have been carried out to investigate whether it might be possible the use of fly ash in fly ash based roof tiles for residential construction. In the present study, treated fly ash (TFA) of C category was used with different materials as a replacement of clay for making treated fly ash stone dust roof tiles (TFASDRT). Treated fly ash stone dust roof tiles (TFASDRT) were studied at varying percentages of cement, coarse sand, and radish stone dust (RSD) along with the constant percentage of waste polythene fibre (WPF). A research program was undertaken to evaluate the suitability of such test for assessing the properties of treated fly ash stone dust roof tiles (TFASDRT). The result of this study recommends that the fly ash based roof tiles provides a sustainable supplement to the traditional clay roof tiles, they increase the efficiency of traditional roof tiles and significantly help to reduce the environmental issues associated with the disposal of these waste materials.

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