Introduction: The epilepsy associated co morbidities are often underestimated, consequently, undertreated. The aim of the present study was to determine neurodevelopmental co morbidities associated with poorly controlled childhood epilepsy. Materials and Methods: This retrospective study was performed from January 2007 to December 2008 at Paediatric Neurology outpatient department in Bangabandhu Sheikh Mujib Medical University, Dhaka, among the children with epilepsy of 7 months to 15 years age who had history of at least 6 months treatment with rational antiepileptic drugs daily with adequate compliance. There were two groups of patients; group 1, consisted of 50 poorly controlled epilepsy patients and group 2, comprised 50 well-controlled epilepsy patients. We retrospectively reviewed EEGs and medical records from these children. Features of neurolodevelopmental co morbidities were compared between the two groups. Results: In this study, initial EEG was abnormal significantly in poorly controlled group (OR= 5.27; p=0.025). Co morbidities- cerebral palsy, language and speech delay, motor delay, microcephaly and cognitive disability were significantly higher in poorly-controlled epilepsy group compared to well-controlled epilepsy group (60.0% vs. 24.0%, p <0.001; 74.0% vs. 38%, p <0.001; 72% vs. 40%, p <0.01; 60% vs. 30.0%, p <0.01; 70% vs 32%, p <0.001 respectively). Conclusion: The study showed several neurodevelopment co morbidities that can be identified early in the course of childhood epilepsy which can predict development of poor seizure control. Knowledge of these co morbidities will help us to discriminate our patient and can inform therapeutic choices. Medicine Today 2021 Vol.33(1): 65-70

Background: Genetic characteristics (allelic and genotypic frequencies; phenotypic distribution) of ABO and rhesus (D) blood group systems of Bengali population from Feni, Noakhali and Sherpur districts are unknown. This has stimulated us to conduct the study. Materials and methods: A retrospective study (2013-2015) was done from blood group data obtained from the registers of the blood banks in district hospitals of Feni, Noakhali and Sherpur. Hardy- Weinberg formula was used to determine allele and genotype distribution. Results: Total subjects from the three centers were 8058. Observed allelic (O > B > A) and phenotypic frequency (O > B > A > AB) was similar in all centers. Allele frequency range was IA 0.1826 to 0.1946, IB 0.2082 to 0.2292 and IO 0.5768 to 0.6092. Rhesus (D) allele frequency was Id 0.1315 to 0.1615 and ID 0.8385 to 0.8685. Rhesus negative blood groups were scarce (%). Conclusion: Genetic characteristics of ABO and rhesus blood group genes of studied population are in agreement with the existing data about Bangladeshi population. JCMCTA 2017 ; 28 (1) : 38 - 41

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Introduction:The aim of the present study was to determine clinical factors associated with poorly controlled epilepsy. Materials and Methods: This retrospective study was performed from January 2007 to December 2008 at Paediatric Neurology outpatient department in Bangabandhu Sheikh Mujib Medical University, Dhaka, among the children with epilepsy of 7 months to 15 years age who had history of at least 6 months treatment with rational antiepileptic drugs daily with adequate compliance. There were two groups of patients; group 1, consisted of 50 poorly controlled epilepsy patients and group 2, comprised 50 well-controlled epilepsy patients. We retrospectively reviewed EEGs and medical records from these children. Features of clinical findings were compared between the two groups. Results: In this study, age of onset of initial seizure before 1 year, mixed type of seizure, infantile spasm, high initial seizure frequency (daily seizure), symptomatic etiology, mental retardation, neonatal seizure and more than 20 seizures before starting treatment were also found to be significant clinical predictors of poorly controlled epilepsy. Multivariate analysis detected 2 independent clinical predictors of poorly controlled epilepsy: mixed seizures and more than 20 seizures before starting treatment. Conclusions: The study showed several clinical factors that can be identified early in the course of childhood epilepsy which can predict development of poor seizure control. Knowledge of these factors will help us to discriminate our patients and pay more attention to those at risk of developing poorly controlled epilepsy. Medicine Today 2020 Vol.32(2): 85-90