Expansion of arid lands due to climate change, particularly in water stressed regions of the world can have severe implications on the economy and people’s livelihoods. The spatiotemporal trends in aridity, the shift of land from lower to higher arid classes and the effect of this shift on different land uses in Syria have been evaluated in this study for the period 1951–2010 using high-resolution monthly climate data of the Terrestrial Hydrology Research Group of Princeton University. The trends in rainfall, temperature and potential evapotranspiration were also evaluated to understand the causes of aridity shifts. The results revealed an expansion of aridity in Syria during 1951–1980 compared to 1981–2010. About 6.21% of semi-arid land was observed to shift to arid class and 5.91% dry-subhumid land to semi-arid land between the two periods. Analysis of results revealed that the decrease in rainfall is the major cause of increasing aridity in Syria. About 28.3% of agriculture land located in the north and the northwest was found to shift from humid to dry-subhumid or dry-subhumid to semi-arid. Analysis of results revealed that the shifting of drylands mostly occurred in the northern agricultural areas of Syria. The land productivity and irrigation needs can be severely affected by increasing aridity which may affect food security and the economy of the country.