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Cerebral blood flow dysregulation is often associated with hypertension. We hypothesized that a beetroot juice (BRJ) treatment could decrease blood pressure and cerebrovascular resistance (CVR). We subjected 12 healthy females to control and BRJ treatments. Cerebrovascular resistance index (CVRI), systolic blood pressure (SBP), total vascular resistance (TVR), and the heart rate-systolic pressure product (RPP) measured at rest and at two exercise workloads were lower after the BRJ treatment. CVRI, SBP, and RPP were lower without a lower TVR at the highest exercise level. These findings suggest improved systemic and cerebral hemodynamics that could translate into a dietary treatment for hypertension.

Previous studies have shown that beetroot juice (BJ) decreases systolic blood pressure (SBP) and oxygen demand. This study tests the hypothesis that a beetroot juice (BJ) treatment increases heart rate variability (HRV) measured by the average standard deviation of normal-normal electrocardiogram RR intervals (SDNN) and the low frequency (LF), mainly sympathetic, fast Fourier transform spectral index of HRV. The subjects were 13 healthy young adult African-American females. Placebo control orange juice (OJ) and BJ treatments were given on separate days. Blood nitric oxide [NO], SBP and RR intervals were measured at rest and at constant workloads set to 40% and 80% of the predetermined VO2peak. Two hours after ingestion the BJ treatment increased [NO] and decreased SBP. BJ also increased SDNN at rest and at the 40% VO2peak workload, without significant effects on LF. SDNN was significantly greater after the BJ than after the OJ treatment, across the two physical activity conditions and SDNN was (negatively) correlated with SBP. These results suggest that BJ decreases SBP and increases HRV at rest and during aerobic exercise. Similar results in subjects with prehypertension or hypertension could translate to a dietary nitrate treatment for hypertension.

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Tight gas reservoirs normally have production problems due to very low matrix permeability and different damage mechanisms during drilling, completion and stimulation. Tight reservoirs need advanced drilling and completion techniques to efficiently connect wellbore to the formation open natural fractures and produce gas at commercial rates. Stress regimes have significant influence on tight gas reservoirs production performance. The stress regimes cause wellbore instability issues while drilling, which can result in large wellbore breakouts. The stress regimes can also control the well long-term production performance, since they affect permeability anisotropy. The preferred horizontal flow direction is expected to be parallel to the maximum in situ horizontal stress. The production and welltest data in non-fractured as well as hydraulically fractured wells in tight reservoirs have indicated the presence of a long-term linear flow regime due to the well and reservoir geometry and also as a result of the permeability anisotropy. The stress anisotropy leads to different permeabilities in different directions, and the natural fractures that are aligned with maximum horizontal stress; they might have larger aperture and greater permeability. Due to the more severe stress anisotropy in tight formations, permeability in maximum stress direction might significantly be larger than permeability in the direction of minimum stress. This study represents evaluation of parameters that might control well productivity and long-term well production performance in tight gas reservoirs. Geomechanical modeling is performed in order to understand the effect of stress anisotropy on aperture evolution of natural fractures in different directions. Furthermore, single well reservoir simulation study is performed in order to generate pressure build-up data for a typical tight gas reservoir, in order to evaluate effect of reservoir geometry and permeability anisotropy on late time linear flow regime, and also assess the well production performance for different well and reservoir conditions.