Short courses of PTZ/VAN were not associated with a greater risk of short- or 60-day adverse renal outcomes compared to other empiric broad-spectrum combinations.

The objectives of this paper in the context of aerosol jet printing (AJP)—an additive manufacturing (AM) process—are to: (1) realize in situ online monitoring of print quality in terms of line/electronic trace morphology; and (2) explain the causal aerodynamic interactions that govern line morphology based on a two-dimensional computational fluid dynamics (2D-CFD) model. To realize these objectives, an Optomec AJ-300 aerosol jet printer was instrumented with a charge coupled device (CCD) camera mounted coaxial to the nozzle (perpendicular to the platen). Experiments were conducted by varying two process parameters, namely, sheath gas flow rate (ShGFR) and carrier gas flow rate (CGFR). The morphology of the deposited lines was captured from the online CCD images. Subsequently, using a novel digital image processing method proposed in this study, six line morphology attributes were quantified. The quantified line morphology attributes are: (1) line width, (2) line density, (3) line edge quality/smoothness, (4) overspray (OS), (5) line discontinuity, and (6) internal connectivity. The experimentally observed line morphology trends as a function of ShGFR and CGFR were verified with computational fluid dynamics (CFD) simulations. The image-based line morphology quantifiers proposed in this work can be used for online detection of incipient process drifts, while the CFD model is valuable to ascertain the appropriate corrective action to bring the process back in control in case of a drift.

The objective of this work is to develop and apply a spectral graph theoretic approach for differentiating between (classifying) additive manufactured (AM) parts contingent on the severity of their dimensional variation from laser-scanned coordinate measurements (3D point cloud). The novelty of the approach is in invoking spectral graph Laplacian eigenvalues as an extracted feature from the laser-scanned 3D point cloud data in conjunction with various machine learning techniques. The outcome is a new method that classifies the dimensional variation of an AM part by sampling less than 5% of the 2 million 3D point cloud data acquired (per part). This is a practically important result, because it reduces the measurement burden for postprocess quality assurance in AM—parts can be laser-scanned and their dimensional variation quickly assessed on the shop floor. To realize the research objective, the procedure is as follows. Test parts are made using the fused filament fabrication (FFF) polymer AM process. The FFF process conditions are varied per a phased design of experiments plan to produce parts with distinctive dimensional variations. Subsequently, each test part is laser scanned and 3D point cloud data are acquired. To classify the dimensional variation among parts, Laplacian eigenvalues are extracted from the 3D point cloud data and used as features within different machine learning approaches. Six machine learning approaches are juxtaposed: sparse representation, k-nearest neighbors, neural network, naïve Bayes, support vector machine, and decision tree. Of these, the sparse representation technique provides the highest classification accuracy (F-score > 97%).

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This work proposes a novel approach for geometric integrity assessment of additive manufactured (AM, 3D printed) components, exemplified by acrylonitrile butadiene styrene (ABS) polymer parts made using fused filament fabrication (FFF) process. The following two research questions are addressed in this paper: (1) what is the effect of FFF process parameters, specifically, infill percentage (If) and extrusion temperature (Te) on geometric integrity of ABS parts?; and (2) what approach is required to differentiate AM parts with respect to their geometric integrity based on sparse sampling from a large (∼ 2 million data points) laser-scanned point cloud dataset? To answer the first question, ABS parts are produced by varying two FFF parameters, namely, infill percentage (If) and extrusion temperature (Te) through design of experiments. The part geometric integrity is assessed with respect to key geometric dimensioning and tolerancing (GD&T) features, such as flatness, circularity, cylindricity, root mean square deviation, and in-tolerance percentage. These GD&T parameters are obtained by laser scanning of the FFF parts. Concurrently, coordinate measurements of the part geometry in the form of 3D point cloud data is also acquired. Through response surface statistical analysis of this experimental data it was found that discrimination of geometric integrity between FFF parts based on GD&T parameters and process inputs alone was unsatisfactory (regression R2 < 50%). This directly motivates the second question. Accordingly, a data-driven analytical approach is proposed to classify the geometric integrity of FFF parts using minimal number (< 2% of total) of laser-scanned 3D point cloud data. The approach uses spectral graph theoretic Laplacian eigenvalues extracted from the 3D point cloud data in conjunction with a modeling framework called sparse representation to classify FFF part quality contingent on the geometric integrity. The practical outcome of this work is a method that can quickly classify the part geometric integrity with minimal point cloud data and high classification fidelity (F-score > 95%), which bypasses tedious coordinate measurement.