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Using the tight-binding (TB) approximation with inclusion of the spin-orbit interaction, we predict a topological phase transition in the electronic band structure of phosphorene in the presence of axial strains. We derive a low-energy TB Hamiltonian that includes the spin-orbit interaction for bulk phosphorene. Applying a compressive biaxial in-plane strain and perpendicular tensile strain in ranges where the structure is still stable, leads to a topological phase transition. We aslo, examine the influence of strain on zigzag phosphorene nanoribbons (zPNRs) and the formation of the corresponding protected edge states when the system is in the topological phase. For zPNRs up to a width of 100 nm the energy gap is at least three orders of magnitude larger than the thermal energy at room temperature.

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Objective: To evaluate the impact of a clinical pharmacist managed medication refill clinic on physician workload. Methods: A retrospective case study was conducted for patients receiving refill authorizations or denials from the clinical pharmacist from 2008 to 2010. Data related to refill request volume and interventions undertaken were collected. Results: A total of 5706 refill requests were processed by the clinical pharmacist during the study period. The collaboration decreased physician refill request volume up to 60%. Of the total amount of refill requests processed, 42% required the pharmacist to make an intervention. The most common interventions were reminders for follow-up. Conclusion: The collaboration between a clinical pharmacist and family physicians to develop a clinical pharmacist managed medication refill clinic decreased physician workload and improved patient care.