Schiff bases are versatile ligands, synthesized via condensation of primary amines with carbonyl compounds. In this study, equimolar amounts of 4-imidazolecarboxaldehyde and thiosemicarbazide were combined and the Schiff base 4-imidazolecarboxaldehyde thiosemicarbazone was prepared as a new bidentate complexing agent. The synthesized ligand was reacted with palladium (II) and platinum (II) ions yielding air-stable complexes. For characterization purpose, infrared spectra, mass spectra, electronic spectra, thermal analysis, proton nuclear magnetic resonance and 13-carbon nuclear magnetic resonance spectra studies were carried out on the obtained complexes and ligand. The characterization data showed that the ligand acts as a bidentate coordinate to the metal ions through azomethine nitrogen and sulfur atoms. An in vitro antimicrobial investigation was also carried out for the free ligand and its metal complexes against four bacteria; Bacillus cereus, Staphylococcus aureus (Gram-positive), Escherichia coli and Salmonella typhimurium (Gram-negative) and one Fungi; Candida albicans, to assess their antimicrobial properties by disc diffusion technique. Antimicrobial activity of the prepared complexes showed higher activity than the free ligand.

Schiff bases are the most widely used organic compounds. They have been shown to exhibit a broad range of biological activities, including; antifungal, antibacterial, antimalarial, anti-proliferative, anti-inflammatory, antiviral, and antipyretic properties. In this study semicarbazone ligand was prepared by condensing 3-nitropenzaldehyde with semicarbazide hydrochloride in 1:1 molar ratio in ethanolic medium. This ligand was used to synthesize metal complexes of copper (II) and nickel (II) in 1:2 molar ratio using ethanol as a solvent .Characterization and structure elucidation of prepared metal complexes have been investigated on the basis of molar conductance and UV and IR spectral studies. The all prepared compounds showed a vital effect against both types of bacteria gram positive (Staphylococcus-aurous) and gram negative (Escherichia-coli).

No abstract

This study was carried out to evaluate the antioxidant (anticarcinogenic) effect of some vegetables (celery, green pepper and broccoli) to prevent the risk of precrcinogenic diets (10% oil used several times for fring) in the experimental animals. The results showed that the animals treated with vegtables exerted a positive effect on daily body weight, food conversion ratio, triglyceride, low density lipoprotein cholesterol (LDLc,) cholesterol, and total lipid. The inhibitory effect of vegetables on liver and renal function which was demonstrated by decreased concentrations of aspartate amino transferase (AST), (ALT), uric acid and creatinine. It could be also shown from results that vegetables diet caused significant effect in some blood parameters and blood picture. Also, laboratory analysis had beneficial effect on relative weight of liver, spleen, kidenys and brain. The experimental rats showed different pathological changes varied from mild to sever inflammation and adenoma in different organs of spleen, brain, liver, and kidneys. From this study, it is concluded that, consumption of vegetables can lower the risk of very fried oil. such as ascorbic acid (Vitamin C), urate and glutathione as well as lipophilic radical scavengers such as tocopherol (Vitamin E), carotenoids and flavonoids. Therefore, vegetables could conceivably protect against the molecular effects of lipid peroxidation, free radicals and ROS and also delay the progress of many chronic diseases (Lai et al., 2001 and Gulacin et al., 2003). The present study was designed to determine some chemical composition in some vegetables (green pepper, celery and broccoli) as antioxidant sources. We focused our attention on its effects on the serum lipid pattern parameters, liver function, kidneys function, test of some blood indicators and enzymes, as well as the histopathological examination of liver, kidneys, spleen and brain. MATERIALS AND METHODS Materials :-Fresh vegetable: Celery (Apium graveolens), broccoli (Brassico oleracea) and green pepper (Capsicum annum) were obtained from the local markets and were dried at 60 °C, and crushed to powder. Oil used several time for frying for not less about 50 hours. Experimental animals; this work was carried out 45 adult male of white albino mices of Sprague dawely strain. The mean weight of male rats ranged from 16 to 19 g. Provided from National Research Center, Cairo, Egypt, were housed as groups in wire cages under the normal laboratory conditions and fed on basal diet according to NRC 1995. Food and water was provided adlibtum. The standard diet was composed as following :-200g casein, 497g Corn starch, 100g Sucrose, 20g Vitamin mixture, 100g Mineral mixture, 50g Corn oil, 3g DL-methionine, 30g Cellulose. Methods :-Chemical Analysis :-Moisture, ash, crude protein, crude fat, and crude fiber were determined according to the methods of the (A.O.A.C.1990). While, total carbohydrates were estimated by subtracting the difference from initial weight of the samples as follows : % Carbohydrates = 100-(% moistur...

Schiff bases are regarded as “privileged ligands” due to their capability to form complexes with a wide range of transition metal ions yielding stable and intensely colored metal complexes. In this study, equimolar amounts of 4-methyl-5-imidazolecarboxaldehyde and thiosemicarbazide were combined and the Schiff base 4-methyl-5-imidazolecarboxaldehyde thiosemicarbazone was prepared as a new bidentate complexing agent. The synthesized ligand was reacted with palladium (II) and platinum (II) ions yielding air-stable complexes. For characterization purpose, mass spectra and x-ray analysis of the ligand and infrared spectra, electronic spectra, thermal analysis, proton nuclear magnetic resonance and 13-carbon nuclear magnetic resonance spectra studies were carried out on the obtained ligand and its complexes. The characterization data showed that the ligand acts as a bidentate coordinate to the metal ions through azomethine nitrogen and sulfur atom. An in vitro antimicrobial investigation was also carried out for the free ligand and its metal complexes against four bacteria; Bacillus cereus, Staphylococcus aureus (Gram-positive), Escherichia coli and Salmonella typhimurium (Gram-negative) and one Fungi; Candida albicans. The results showed that the antimicrobial activity of the prepared complexes showed higher activity than the free ligand.