Background: Helicobacter pylori (H. pylori) is the microorganism responsible for the most frequent and persistent bacterial infection worldwide. irolyp.H infection affects nearly half of the world's population. In the developing countries, the prevalence of infection is as high as 90%, whereas in the developed countries, excluding Japan, the prevalence is below 40% (1). An association between iro olyp.H infection and skin diseases such as chronic idiopathic urticaria and atopic dermatitis has been suggested (2). Aim of the work: this review aimed to focus on the relationship between Helicobacter pylori, chronic idiopathic urticaria and atopic dermatitis. This association was reviewed in the following lines. Methodology: we used scientific websites such as PubMed, Google Scholar and Research Gate to get related articles about this subject. Results: several studies have reported the presence of H. pylori DNA in environmental water sources. Diagnostic tests are usually divided into invasive (endoscopic-based) and noninvasive methods. Using proton-pump inhibitors (PPIs) in combination with several antibiotics such as amoxicillin plus clarithromycin or metronidazole have been considered as the first-line treatment. Conclusion: H. pylori has a great prevalence among world's population. H. pylori infection could play a role in the pathogenesis of a variety of skin diseases.