Check for updatesand finally carrier of a vesical catheter. The ultrasound exploration showed a prostate enlargement which volume was estimate to 60g with intravesical prostate protrusion. In the bladder was the presence of multiple stones.The Kidney, Ureter, and Bladder (KUB) X-ray revealed an intravesical necklace drawn by small stones (Figure 1). The rest of biologic assessment was normal. An open prostatectomy was indicated in front of this clinical picture. An enucleation of prostatic adenoma, and removal of the stones were performed.Figure 1A shows the patient's KUB showing the arrangement of intravesical necklace calculi, Figure 1B

Scrotal elephantiasis is a rare pathology Peno-scrotal elephantiasis (scrotal lymphedema) is most common in endemic filarian areas. Outside these areas this pathology remains quite rare. We report a case of primitive peno-scrotal elephantiasis. A 60-year-old patient with no significant pathological history, who had a significant increase of the bursa volume that had been evolving for years. The clinical examination found a bursary 46 cm in diameter with thickened skin and a penis buried in a glove finger. Exploration of the vascular axis of the lower limbs was normal. Peri-scrotal MRI noted significant infiltration of inflammatory-looking scrotal tunics, but found no obstructive cause. The patient was treated by a complete surgical resection of the pathological tissue and a peno-scrotal reconstruction. The evolution was marked by a progressive healing of the surgical wound, the patient was reviewed several times to assess the benefit of the treatment, he noted a satisfaction of the surgery allowing a good functional and aesthetic result. The aim of this case report is to present a specific management of a peno-scrotal elephantiasis in our hospital and to compare it with the review of literature on surgical management of this pathology. This condition is uncommon and challenging to manage for most urologists.

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INTRODUCTION: In Morocco, Kidney cancer is the 18th most common tumour and the 19th lethal cancer in 2020. The average age of diagnosis is 65 years and men are more affected. Molecular studies of renal cell carcinoma (RCC) allowed the detection of several genetic abnormalities in each histological subtype. These aberrations got different diagnostic value, prognostic implication and for some, therapeutic utility. The aim of our study is to evaluate the utility of fluorescence in-situ hybridization (FISH) in the diagnosis and the prognosis of renal cell carcinoma. MATERIAL AND METHODS: We included prospectively cases of RCC diagnosed after histological examination and immunohistochemistry analysis for some cases. The methodology consisted in highlighting by FISH method, molecular abnormalities for each histological subtypes using Zytolight® probes. Probes were chosen depending on the histological diagnosis. RESULTS: A total of 23 case of RCC were included. Clear cell carcinoma (ccRCC) represented 47,8% (11 cases) followed by papillary RCC (pRCC) with 26%, chromophobe RCC (chRCC) with 13%, a case with uncertain diagnosis, ccRCC or pRCC (4,3%), one case of renal oncocytoma (RO) (4,3%), and a case of tubulo-cystic RCC (4,3%). FISH method supported the morphological diagnosis in all cases except in one biopsy diagnosed histologically as a ccRCC and this method allowed the diagnosis correction to pRCC by the detection of chromosome 17 polysomy described in this histological subtype. FISH can also be used in the prognostic categorization of patients by detecting of some genetic aberrations with a prognostic implication like CDKN2a loss which predict a worse evolution. CONCLUSION: FISH method got an implication in the diagnostic approach of RCC, especially in cases with non-conclusive histology and immunohistochemistry. It can also be used in the prognosis in addition to other histo-prognostic factors. This method will lead to more precision in diagnosis and better care management personalization.