Bacillus Calmette and Guérin (BCG), widely used as a vaccination to prevent tuberculosis, is also used as immunotherapy, by intrabladder instillation, to treat superficial bladder cancers and prevent recurrence. Complications following instillation of BCG are most often localized reactions, such as cystitis or hematuria. They can more rarely be generalized and potentially severe such as hepatitis, pneumopathies, aortitis, and localization to hematopoietic tissue. We have reported the observation of a 47-year-old patient followed up for a bladder tumor operated for transurethral resection of the bladder, then having benefited from an instillation of BCG therapy complicated by occurrence a week later of an acute hepatitis. The diagnostic time was 2 days, and the outcome was favorable with corticosteroid therapy.

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Check for updatesand finally carrier of a vesical catheter. The ultrasound exploration showed a prostate enlargement which volume was estimate to 60g with intravesical prostate protrusion. In the bladder was the presence of multiple stones.The Kidney, Ureter, and Bladder (KUB) X-ray revealed an intravesical necklace drawn by small stones (Figure 1). The rest of biologic assessment was normal. An open prostatectomy was indicated in front of this clinical picture. An enucleation of prostatic adenoma, and removal of the stones were performed.Figure 1A shows the patient's KUB showing the arrangement of intravesical necklace calculi, Figure 1B