The use of oral terbinafine in the treatment of superficial dermatophyte infections has been extensively studied, using different treatment regimens. To evaluate the efficacy of short-term therapy with oral terbinafine in cases of tinea cruris/corporis, 22 patients (21 male and one female) with mycologically proven tinea cruris/corporis, were included in the present study. Each patient received one tablet of terbinafine 250 mg daily for 1 week. Patients were followed-up for 6 weeks after completion of treatment. Clinical and mycological assessments were performed at the end of treatment, and at the end of the follow-up period. The mean sum of scores of signs and symptoms in all patients decreased significantly from 12.36 before treatment to 0 at the end of the follow-up period, and mycological investigations were negative in all patients at the end of the follow-up period. Our results show that 1-week therapy with oral terbinafine is highly effective in the treatment of tinea cruris/corporis.
<p class="abstract"><strong>Background:</strong> Adult segmental vitiligo treated by narrow band ultraviolet B (NB-UVB) showed delayed repigmentation. This study is being undertaken to determine the efficacy of topical olive oil addition before (NB-UVB) sessions for vitiligo patients (pts).</p><p class="abstract"><strong>Methods:</strong> Randomized controlled trial (RCT) enrolled ten volunteers suffering segmental vitiligo on both upper limbs, all patients left limb was tested by topical olive oil before each NB-UVB session and twice daily in session free days for a total of 20 sessions (46 days), the right upper limb was the control (only NB-UVB), each site response was assessed based on time of appearance of erythema and repigmentation. Statistical analysis was done by the Chi-square test.<strong></strong></p><p class="abstract"><strong>Results:</strong> All patients were ten, seven were female (70%), three males (30%) of middle age group, university graduates live in Khartoum state. Their left upper limbs showed erythema in <3 sessions in five pts (50%) and three-five sessions in (50%), repigmentation started in <3 sessions in one patient (10%) and three-four sessions in five pt. (50%) and >5 sessions for four pts (40%), pattern of repigmentation was marginal in eight pts (80%), mixed in two pts (20%). Their right upper limbs showed erythema in three-four sessions in two pts (20%) and eight pts (80%) needed five sessions, repigmentation started after five sessions in all patients (100%), pattern of repigmentation was follicular in one pts (10%), marginal in five pts (50%), mixed in four pts (40%).</p><p class="abstract"><strong>Conclusions:</strong> Addition of topical olive oil to NB-UVB for segmental vitiligo patients showed earlier occurrence of repigmentation and better pigmentation pattern.</p>
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