Primary knee osteoarthritis is an extremely common cause of disability of lower extremities which results due to breakdown and destruction of joint tissues. The present study was designed to evaluate the efficacy of Majoon Yahya bin Khalid and local application of Roghan Darchini in management of Primary Knee Osteoarthritis. It was an open label evaluation study for the duration of 30 days carried out on 30 patients aged between 35 to 60 years at NIUM hospital, Bengaluru, from April 2014 to Feb 2015. After taking written voluntary informed consent, test drugs Majoon Yahya bin Khalid was given 9 gm orally twice a day, and Roghan Darchini 2-3 ml for local application on the affected knee joints once a day. Subjective as well as objective parameters were evaluated at baseline, 15th and 30th day. The results were analyzed using paired proportion and paired student t tests. Significant improvement was observed in subjective parameters of joint pain and restriction of movements with p <0.001. All the five subscales of objective parameter (Knee Osteoarthritis Outcome Score) were found to be highly significant with p <0.001. The study revealed that the test drugs are effective and safe in management of primary knee osteoarthritis.

Dyslipidaemia is a leading medical problem affecting overall health status of an individual. Deranged levels of lipid profile are responsible for atherosclerosis which ultimately leads to development of vascular diseases. If left untreated, it may result in various life threatening complications. Objective was to compare and evaluate the efficacy of test drug Qurs-e-Luk with control drug "Lipotab" in the management of Dyslipidaemia. It was a single blind, randomized, controlled, clinical trial. Thirty subjects of dyslipidaemia were selected and randomly assigned to test (20 patients) and control group (10 patients). Qurs-e-Luk and Lipotab were given to test and control groups in the form of powder (5 gm twice a day) and tablet (2 tablets per day) respectively for 60 days. All the patients of both groups were assessed on subjective and objective parameters at the baseline and after completion of trial, and the study outcome was analyzed using appropriate statistical tests. The test drug showed significant effect on few subjective and objective parameters in comparison to control drug without any significant side effects or toxicity. In test group, improvement in palpitation, fatigue and reduction in S. triglycerides and LDL was statistically significant (p < 0.05). The study infers that the comparative analyses of both drugs was not statistically significant; although improvement in subjective parameters was noted in both groups, and the effect on objective parameters was observed only in test group.

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The Unani system of medicine is one of the ancient systems of medicine. Hippocrates (460-377 BC) was the first person who had freed medicine from superstitious believes and provided the base for the foundation of medicine and given the theory of Akhlat (Humours). In Unani system of medicine human body contains four humours that is Dam (sanguine), Balgham (phlegm), Safra (yellow bile) and Sauda (black bile). For the maintenance of health it is important that overall effect or combined effects of the humours are in accordance with the Mizaj (temperament) of the individual. In Unani medicine massage is known as Dalk. It has been extensively used for its preventive, therapeutic and rehabilitative purposes since ancient times. It causes elimination of morbific matter out of the body, thus helps in maintaining the equilibrium of humors. It has been advised in management of myriad neurological, psychosomatic and musculoskeletal disorders. Various clinical trials have established its efficacy in these diseases on scientific parameters. This review article aims to explore the basic concept, classification and its therapeutic importance in musculoskeletal diseases.

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