The aqueous and ethanolic extracts of C. grandis (Family: Leguminosae) were evaluated for antidiabetic activity by a glucose tolerance test, in normal rats and alloxan-induced diabetic rats. The aqueous and ethanolic extracts showed that they significantly lowered the blood glucose levels to normal in the glucose tolerance test. In alloxan-induced diabetic rats the maximum reduction in blood glucose was observed after three hours, at a dose level of 150 mg/kg of body weight. The percentage of protection given by the aqueous and ethanolic extracts was 32.72 and 46.42%, respectively. In the long-term treatment of alloxan-induced diabetic rats, the degree of protection was determined by measuring the blood glucose, cholesterol, and triglycerides on the tenth day. Both the extracts showed a significant antidiabetic activity comparable to that of glibenclamide. These results showed that the Cassia grandis possessed significant antidiabetic activity.

The antidiabetic potential of the alcohol root extract of Holostemma annulare Schum. (Asclepiadaceae), a medicinal plant widely used in more than 34 Ayurvedic preparations, was evaluated in the streptozotocinnicotinamide-induced type 2 diabetic model. Graded doses of the alcohol root extract were administered to normal and experimental diabetic rats for 15 days. A significant (p < 0.05) reduction was observed in the fasting blood glucose levels of normal as well as diabetic rats. Serum insulin levels were stimulated in the diabetic animals treated with the extract. Body weight, serum lipid profiles, serum urea and creatinine levels were estimated in extract-treated normal and diabetic rats. In addition, glycosylated hemoglobin and liver glycogen levels assessed in the extract-treated diabetic rats were compared with diabetic control and normal animals. Significant results were observed in the estimated parameters, thereby justifying the use of the plant in the treatment of diabetes mellitus.

Medicinal plants are well-known sources of important therapeutic aid for alleviate human disorders. (Elaeocarpaceae) is the widely used in the ayurvedic system of the medicine as very sweet, musky, fig-like flavour. also known as Jamaica cherry, is a small and evergreen tree. The necessity of plant in human ailments is illustrious in old medicinal practices. The secondary metabolites are obtained from the different parts of plant alkaloids, flavonoids, tannin, phenolic compound etc. are traditional medicinal uses have been reported for the leaves (headaches, prostate problems, reduce gastric ulcers), bark (antiseptic), flowers (antiseptic, reduce swelling, antispasmodic), and fruits (respiratory problems, antidiarrheic). The present study gives an overview on plant and its pharmacological activities were documented.

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