Background: Diabetes accounts for almost 6% of total global mortality, with 50% of diabetesassociated deaths being attributed to cardiovascular disease (CVD). Prevalence of type 2 diabetes in rural Bangladeshi and in urban Bangladeshi is found to be 7.2% and 10.5% respectively. People of developing countries suffer from the disease at earlier age than that of developed countries. Among the diabetic patients, vascular complications represent a major cause of morbidity and mortality. Diabetes is commonly accompanied by other cardiovascular risk factors: dyslipidemia, hypertension, and increased prothrombotic factors. Total plasma homocysteine (tHcy) is an emerging CVD risk factor. Insulin resistance and hyperinsulinemia in diabetes mellitus along with increased homocysteine is thought to cause endothelial dysfunction. Endothelial dysfunction together with other factors such as dyslipidemia, microalbuminemia etc. causes cardiovascular disease.Objectives: Objective of the study was to evaluate serum total homocysteine level and to correlate it with fasting lipid profile in type 2 diabetic patients.Methodology: This cross sectional study was conducted during the period of July 2011- June 2013 on 95 patients of type 2 diabetes mellitus, attending the Endocrine OPD of Bangabandhu Sheikh Mujib Medical University (BSMMU). The study was carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka. Study subjects were selected by purposive and convenient sampling technique.Result: Study subjects were categorized according to the presence or absence of hyperhomocysteinemia. Among the total study population hyperhomocysteinemia was found in 21.05 %. Among them number of male was greater. The study population had mean serum total cholesterol 198.34±39.62(mg/dl), triacylglycerol 198.91±116.71(mg/dl), LDL 126.75±35.38(mg/ dl), HDL 34.35±8.31(mg/dl), TC:HDL=15.67±6.07:1,and LDL:HDL=9.94±3.88:1 Independant sample t test showed that there was significant inverse association of hyperhomocysteinemia with HDL. Other parameters of lipid profile and lipid ratios did not show any significant association.Conclusions: Around one fifth of the type 2 diabetic patients had hyperhomocysteinemia. Significant inverse association was present between hyperhomocysteinemia and HDL. Other parameters of lipid profile and lipid ratios did not show any significant association.J Shaheed Suhrawardy Med Coll, June 2018, Vol.10(1); 42-46

Background: Type 2 diabetic patients are presented with dyslipidemia. Objective: The objective of this study was to see the association between the HbA1c and lipid profiles among the diabetic subjects. Methodology: The cross-sectional study was carried in the Department of Biochemistry at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh on type 2 diabetic individual attending the endocrine OPD of BSMMU. In this study estimation of HbA1c level and lipid profiles in diabetic subjects were performed and was compared the lipid profiles between the controlled (HbA1c <7%) and uncontrolled (HbA1c >7%) groups. Result: A total number of 95 patients were recruited for this study. The mean age of the respondents was 42.63 ±5.56 years. Female (8.21± 1.88) had lower HbA1c than male (8.42±2.21) in the study. TC: HDL (6.07±1.02:1) and LDL: HDL (3.88±1.58:1) were also higher. Among the study population 30 had good (HbA1c<7 mg%) glycemic control and 14 of them were male and 16 were female. Those having good glycemic control had lower TG and HDL (176.72±88.83 vs 206.84±124.77mg/dl) and (32.84±7.78 vs 34.88±8.48 mg/dl); however, higher TC and LDL (201.56±34.73 vs 197.19 mg/dL) and (133.04±33.71 vs 124.30±35.97 mg/dL) than those having poor glycemic control. No statistically significant difference between these two groups were observed. Conclusion: Thus there is no statistical significant difference between HbA1c and lipid profile among type 2 diabetes mellitus patients. Journal of National Institute of Neurosciences Bangladesh, 2019;5(1): 72-75

Background: Dengue is an acute systemic viral disease that has established itself globally in both endemic and epidemic transmission cycles. The disease is spread by the bite of an Aedes mosquito. Electrolyte disturbances is a major complication in dengue infection. In present study serum sodium, potassium & chloride level was estimated to find the electrolyte abnormality in dengue patients. Material & Methods: This prospective cross sectional study was done on 121 adult patients of “Shaheed Suhrawardy Medical College, Hospital” from August 2019 to April 2020 who were tested positive by NS1 or IgM for dengue. Result: Mean age of dengue patients was 31.17 ± 11.8 yrs. Higher percentage (57.85%) of dengue patients were observed in young age group (i.e. 18-30 yrs.) than any other age group. Mean value of serum electrolytes was 139.34±3.76 meq/L, 4.48±.74 meq/L & 101.1±3.55 meq/L for sodium, potassium & chloride respectively. Mean value of all electrolytes are higher in dengue fever than dengue hemorrhagic fever though there was no significant statistical difference. Among all the dengue patients 10.7% had hyponatremia, 4.1% had hypernatremia and 85.1% had normal serum sodium. Regarding serum potassium status 9.92% had hypokalemia, 17.36% % had hyperkalemia and 72.72% had normal serum potassium. Conclusions: Young male population aged 18-30 yrs is more prone to dengue infection. Common electrolyte disturbances in dengue infection are hyponatremia and hyperkalemia. J Shaheed Suhrawardy Med Coll 2021; 13(2): 105-108