Split-thickness skin grafting (STSG) is widely used to heal wounds resulting from trauma, burns, and chronic wounds. This study aimed to determine the true effect of platelet-rich fibrin (PRF) on patients with burn wounds requiring STSG during treatment of donor wounds. This randomized, triple-blind clinical trial was conducted on patients who referred to the burn ward of Vasei Hospital of Sabzevar, Iran, from May 2017 to May 2018. The donor site was randomly divided into 2 groups: PRF and control (Vaseline petrolatum gauze) using Vaseline gauze. In the intervention group, the PRF gel was applied to the wound and covered with Vaseline gauze and wet dressing. Conversely, only Vaseline gauze and wet dressing were applied to the control group. Outcome evaluation was conducted using paired t test and Wilcoxon signed rank-sum test, as appropriate, on days 8 and 15. The mean age of the patients was 33.10 ± 2.60 years, and 51.50% were male. The mean wound healing time in the PRF and control groups was 11.80 ± 3.51 and 16.30 ± 4.32 days, respectively ( P < .001). The PRF group showed significantly higher wound healing rates than the control group at 8 and 15 days dressing ( P < .001 and P < .001, respectively). Moreover, the mean wound healing for all wound healing indices diagnosed by 2 specialists in PRF was higher than control group on days 8 and 15 ( P < .001). We found a statistically significant difference on days 8 and 15 regarding the mean pain levels between the 2 groups ( P < .001). The findings showed that PRF can significantly increase the time and rate of donor wound healing compared with conventional treatment and also reduce the severity of pain.

Background and Objectives: Vitamin C or ascorbic acid is the most efficient water-soluble antioxidant. Studies show intravenous and oral vitamin C assist with burn healing. However, the effects of topical applications of vitamin C remain unstudied. This study aimed to evaluate the effects of topical vitamin C solution on the granulation tissue reduction of second-degree burn wounds. Methods: This clinical trial was conducted on 30 patients with second-degree burns affecting two or more regions or extended limb areas who had been admitted to the Vasee Hospital burn unit in Sabzevar, Iran during Aug-Dec 2016. In light of the multiple factors influencing burn wound healing, each subject served as his or her own control. Additionally, the depth of burn wounds in each area between limbs of the same patient was similar. Patients routinely received sulfadiazine ointment on two contiguous or separate body parts. Vitamin C solution was applied to one randomly chosen part of the body or one randomly chosen limb. Burn wounds were examined on days one (a baseline measure) and three, seven, and 14 days after the initial assessment, using the Bates-Jensen Wound Assessment Tool. Written informed consent was obtained from the patients prior to the study. Data analysis was performed in SPSS version 20 using repeated measures ANOVA. Results: In the experimental region, the mean granulation score was 5.00 ± 0.00 at baseline and reached 1.83 ± 0.87 on day 14. In the control group, mean granulation score was 5.00 ± 0.00 at baseline and increased to 2.67 ± 0.88 on day 14. On day 14, a significant difference was observed between the mean granulation scores for the experimental and control regions (P = 0.004). Conclusions: Topical administration of a vitamin C solution could be effective in promoting the healing of second-degree burn wounds.

OBJECTIVE To evaluate the effect of amniotic membrane (AM) at split-thickness skin graft (STSG) donor sites. METHODS This double-blind randomized controlled trial was conducted on 35 eligible participants referred to the burn unit of Vasei Hospital of Sabzevar, Iran, during 2017 and 2018. Each STSG donor site was divided into two sides, and the respective halves were covered with either a dried AM or petrolatum gauze (control). Outcomes were evaluated on postprocedure days 10, 20, and 30 using the Vancouver Scar Scale. RESULTS The mean age of the patients was 39.4 ± 13.97 years, and 62.8% (n = 22) were male. There was no statistically significant difference in wound healing rate on day 10 (P = .261), 20 (P = .214), or 30 (P = .187) between groups. The intervention group had significantly better epithelialization than the control group on day 10 (investigator 1, 1.62 ± 0.59 vs 1.40 ± 0.88 [P = .009); investigator 2, 1.22 ± 0.84 vs 0.91 ± 0.85 [P = .003]), as well as pain reduction (P < .001 during the follow-up period). However, there was no statistically significant difference between groups in terms of pigmentation or vascularization (P > .05). CONCLUSIONS Findings suggest that the use of AM is not superior to petrolatum gauze in terms of STSG healing rate; however, AM achieved better pain reduction and epithelialization on day 10.