No abstract

Background: Nephron-sparing surgery is an accepted treatment modality for renal cell carcinoma (RCC) in certain situations. Objectives: The aim of this study was to compare perioperative outcomes after laparoscopic and open partial nephrectomy for patients with a solitary renal tumors of 7cm or less in different institutes in Dhaka. Methodology: Between June 2013 and October 2020, 23 patients had undergone LPN and 24 patients had undergone OPN for the treatment of solitary renal tumors of 7cm or less in different institutes in Dhaka. Large renal mass (>7cm), multiple tumor and patients with complex renal anatomy were excluded from this study. Patients having previous abdominal surgery were excluded from LPN and all LPN were performed transperitoneally. Results: Although the mean operative time was longer in the LPN than in the OPN group (134.4±35.36 (45-180) minutes versus 110.56±35.36 (60-165) minutes; P<0.001), the blood loss was comparable between the two groups (130 mL versus 180 mL; P value is not statistically significant). No blood transfusions were performed in either group. The hospital stay was significantly reduced after LPN compared with after OPN (2.8 days (2-6) versus 6.7 days (5-8); P <0.0002). 2 patients in LPN and 1 patient in OPN had positive surgical margins. Conclusion: This study has revealed that LPN is a feasible and safe alternative to the OPN with better surgical outcomes and similar oncological outcomes. Journal of Current and Advance Medical Research, January 2021;8(1):70-74

Background: Arsenic is a heavy metal and it is considered carcinogenic to humans. In Bangladesh, most of the people consume arsenic polluted water above the nationally accepted level. Several studies have demonstrated that the ingestion of arsenic in drinking water is a strong risk factor for several malignancies including urothelial carcinoma. Clinicopathological features of bladder cancer are related to the amount of arsenic exposure and duration of arsenic exposure into the urinary tract and other risk factors. Aim of the study was to see the relationship between grades of bladder cancers with the level of arsenic in drinking water. Objective: To see the relationship between the grades of bladder cancer with the level of arsenic in drinking water. Materials and Methods: This was a retrospective cross-sectional study done in the department of urology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka. In this study, a total of 72 histopathologically proven urothelial bladder carcinoma and history of at least 10 year underground water consumption patients were enrolled. Among them 12 patients were excluded from the study because no arsenic was found in sample underground drinking water. So, 60 patient was participants for this study. Sample of participant’s drinking water was collected by a selective non-reactive container. The level of arsenic level in microgram/Liter was measured by standard kit method and the level of arsenic was recorded. Results: Arsenic exposure 30 years or more was regardless of the amount of arsenic consumption in drinking water was found high-grade cancer. No significant statistical difference was found in the grading of carcinoma with the level of arsenic in drinking water. Conclusion: Arsenic exposure amount is not related to the grades of bladder cancer rather the duration of arsenic exposure in drinking water is related to the grades of bladder cancer. Bangladesh J. Urol. 2021; 24(2): 141-145

not available Bangladesh J. Urol. 2021; 24(2): 220-223

Objective: To compare the therapeutic effects of solifenacin succinate with extendedrelease tolterodine for the treatment of overactive bladder (OAB) in Bangladeshi patients. Methods: A prospective, randomized, single-blind, two-arm, parallel-group, clinicaltrial was conducted in the department of Urology, Bangabandhu Sheikh Mujib MedicalUniversity (BSMMU), Dhaka from January 2013 to June 2014. A total of 65 patientswith OAB were treated with solifenacin succinate 5 mg (experimental group, n=33)and extended release tolterodine 4 mg (control group, n=32), both at night daily for 12weeks. Efficacy and safety variables were assessed and compared with baseline and at 12weeks treatment in between the two groups. Results: At week 12, solifenacin succinate and extended release tolterodine demonstratedreduction in the mean number of micturition (50% vs. 51%), urgency (87% vs. 73%),urge incontinence (89% vs. 71%), nocturia (89% vs. 74%), usage of pads (90% vs.71%) per 24 hours. There was increased in the mean voided volume of each micturitionin both the groups without any difference in between them. The incidence of major adverseevents were dry mouth (15.2% vs. 9.4%), constipation (9.1% vs. 15.6%), and blurredvision (6.1% vs. 3.1%) respectively. Conclusions: Solifenacin succinate had greater efficacy to extended release tolterodine intreating overactive bladder. There were no significant treatment difference between the twogroups in decreasing the number of micturition and increasing the voided volume of eachmicturition and the incidence of major adverse events. All the adverse effects were mild andtransient in nature and discontinuation of medication due to adverse effects were low. Bangladesh Journal of Urology, Vol. 23, No. 1, January 2020 p.76-81