The journal of Toxicology and pest control is one of the series issued twice by the Egyptian Academic Journal of Biological Sciences, and is devoted to publication of original papers related to the interaction between insects and their environment. The goal of the journal is to advance the scientific understanding of mechanisms of toxicity. Emphasis will be placed on toxic effects observed at relevant exposures, which have direct impact on safety evaluation and risk assessment. The journal therefore welcomes papers on biology ranging from molecular and cell biology, biochemistry and physiology to ecology and environment, also systematics, microbiology, toxicology, hydrobiology, radiobiology and biotechnology. www.eajbs.eg.net

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Histopathological changes in the ovaries were tested in normal adult females and those developed from treated one day old of the fifth nymphal instar of the desert locust with (LC 50) of Consult and Lufox. S. gregaria as well as other orthopterous insects has panoistic ovarioles, each ovariole is divided into a germarium and a vitellarium; the gemarium contains the oogonia and the pre-follicular cells which surround the oocytes to form the ovarian follicles in the vitellarium; and is invested with non-cellular tunica propria and an outer cellular sheath (tunica externa). In the ovarian follicles of those females developed from the treated nymphs with consult showed vacuolization of cytoplasm and degeneration of the cell components of follicular epithelium, oocytes were the most obvious signs of damage. Damage was pronounced in the ovarioles of these females developed from the treated nymphs with Lufox. Ovariole growth was stunted and vitellogenesis and chorion formation were completely inhibited.

Feeding application of different concentrations of Consult on one day old and six day old of the 5 th nymphal instar of the desert locust, Schistocerca gregaria (Forskal) showed mortal action on treated nymphs, failure in ecdysis to adults and prolongation in the 5 th nymphal age and adults had malformed wings, colour changes of body and failure of completely getting rid the last nymphal exuvia.

This study aimed to record the prevalence of different Sarcocystis spp., demonstrate their morphological characters by laboratory, histopathological and immunohistochemical techniques, also to investigate the pathological lesions in esophagus, heart, and brain samples collected from naturally infected donkeys in Egypt. The current study identified four Sarcocystis spp. (S. bertrami, S. equicanis, S. asinus and S. fayeri) in meat samples and S. neurona in the brain of the examined donkeys. Examination of meat samples showed macroscopic tissue cysts of S. bertrami and microscopic tissue cysts of S. equicanis/S. asinus and S. fayeri. According to the thickness of the cyst wall, Sarcocystis spp. were divided into smooth thin walled S. bertrami, ciliated thin walled S. equicanis/S. asius and striated thick walled S. fayeri. Also, immunohistochemical (IHC) examination showed strong labeled schizonts and cyst wall of S. neurona, while the bradyzoites appeared negative staining. Pathological examination revealed degeneration of muscles with intermuscular edema and few mononuclear inflammatory cells, but brain tissue showed perivascular lymphocytic cuffing and satellitosis with developing schizonts. The current study concluded that the accurate recognition about Sarcocystis spp. in donkeys would be helpful in their treatment, prevention and control measures.