<p><strong>Total seed storage protein profiles of 20 urdbean genotypes including the popular variety T9 were analysed by Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). 14 genotypes could be clearly identified based on genotype-specific seed protein fingerprints while rest of the test genotypes were categorized into three protein types. Dendrogram based on electrophoretic data clustered the genotypes into seven groups at 78.5% phenon level.  TU 95-1 with TU 12-25-4 revealed lowest similarity index value (0.33) followed by TU 95-1 with PU 30 and KU 96-3(SI=0.35). Clustering pattern revealed distinctly divergent group formed by TPU 95-1 and TPU 4. These may serve as a valuable source genotype in recombination breeding.   </strong></p><p><strong>Key words: </strong>Seed storage protein profiling, SDS-PAGE, Genetic variation, urdbean.<strong></strong></p>

<p><strong>A set of 292 mungbean germplasm accessions including 62 popularly adapted local land races and two wild forms (<em>Vigna radiata</em> var. sublobata), important breeding lines and standard ruling varieties were screened for drought stress tolerance at seedling stage.  Eight genotypes e.g., C. No. 35, OUM 14-1, OUM 49-2, Pusa 9072, OM 99-3, Banapur local B, Nipania munga, Kalamunga 1-A) have been identified to possess drought tolerance.  Globulin seed storage protein profiling was carried out in 19 selected mungbean genotypes comprising eight drought tolerant, seven drought sensitive, two wild forms of mungbean (TCR 20 and TCR 213) and two standard checks (LGG 460 and T 2-1</strong><strong>)</strong><strong> to explore differentially expressed polypeptides. Seed protein profiles revealed 15 scorable polypeptide bands with molecular weights ranging from 10.0 to 102.2kD. A specific 12.8kD polypeptide band was present in all above drought tolerant test genotypes including the wild accession TCR 20. Such a polypeptide band may serve as useful biochemical marker for identification of drought tolerant genotypes in mungbean. </strong></p><p><strong>            Key words: </strong>Genetic diversity, seed storage protein profile, wild and cultivated <em>Vigna radiata.</em><strong> </strong></p>

N-nitrosamines are potential human carcinogens that can be ingested from a range of known sources, including food, drinking water, tobacco smoke and cosmetic goods. Remarkably, their prevalence in medicinal products went undetected until mid-2018. These contaminants were first detected in the active pharmaceutical ingredient (API) of valsartan and other sartan medicines were eventually implicated. The regulatory response to the nitrosamines issue included a recommendation to all marketing authorization holders (MAHs) for human medicinal products containing chemically synthesized active pharmaceutical ingredients to evaluate the potential hazards of nitrosamines in their products and implement appropriate risk mitigation checks and balances. The objective of this review is to investigate various realms associated with investigating how these genotoxic and carcinogenic impurities may be formed during the manufacture or preservation/storage of a wide range of drugs, including sartans (losartan, valsartan), anti-diabetics (metformin, pioglitazone) and a few antacids (ranitidine) and a thorough literature review on case-studies, drug-excipient interactions, metabolic activation and other prospects.