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Ibrahim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The most common malignant skin diseases are basal cell carcinomas. Their incidence is rising worldwide due to the aging of the population and chronic exposure to the sun. Treatments are varied, but for superficial lesions Imiquimod treatment is also used. We present a case report of 66 years old postmenopausal women, with an erythematous plaque, serous and sanguinolent secretions at the surface on the septal and left nasal ala together with a hemmoragic crust. The signs were present seven years before. In the last period, the lesions have extended and the patient started to use for three consecutive days topical imiquimod. From the second day of administration, intense hyperemia of the lesions and post-scratch erosion it was observed. Threfore, we noted that using imiquimod in postmenopausal women without medical advice, especially in postmenopausal women, could represent a higher risk of skin lesions which need specialized medical treatment.