Introduction: Gastrointestinal stromal tumors are uncommon mesenchymal tumors in the gastrointestinal tract. There is evidence reported of associated secondary neoplasms as synchronic and metachronous tumors. We aimed to describe the patients with synchronous and metachronous gastrointestinal stromal tumors in our reference center. Methods: Review of dataset of a prospectively collected database of 207 patients who underwent surgery for GIST management from 2008 to 2018. Results: 22 patients were included. Mean overall age was 69 (± 8,92) years. Male patients were 63.6%. Gastric was the most common location (68.1%, n=15), followed by small bowel (13.6%, n=3). Immunohistochemistry showed diffuse +CD117 in 100% of the cases. The synchronous tumors group included 11 cases and the most common type of tumor was gastric adenocarcinoma (n=2). For metachronous tumors, the primary localization was the prostate (45.5%, n=5). The most common type of metachronous tumor was prostatic adenocarcinoma (n=5). Conclusion: The stomach was the most common location for synchronous tumors and the prostate for metachronous tumors both being adenocarcinomas. The appearance of these tumors is not as uncommon as reported.

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