Introduction and purpose: Wound healing is a process including complex overlapping stages requiring many components. Adipose tissue is an organ that is responsible for maintaining homeostasis through inflammatory responses, signal transmission, energy expenditure connected with different organs. Fat tissue is a rich and readily available source of multipotent stem cells. Adipose-derived stem cells (ADSCs) have the potential in tissue regeneration because of their self-renewal and ability to differentiate in various types of cells. This review discusses ADSCs in terms of basic knowledge, methods of acquisition, prospects for use in healthcare, focusing mainly on the potential application in the wound healing process. Brief description of the state of knowledge: The article contains current knowledge about biology, specific properties of adipose-derived stem cells and also shows the relationship to the wound healing process. The review presents research that points to the possibility of using ADSCs in future medicine. Conclusions: Adipose-derived stem cells may constitute a prominent role in tissue regeneration owing to the secretion of various cytokines, the ability to differentiate into multiple lineages, their immunomodulatory effects, and the ease of cell obtaining. Further studies are required to explore the accurate mechanism of ADSCs action and their long-term safety in clinical application. Stem cell therapy brings new hope for the repair of chronic and refractory wounds and skin defects.

Introduction and purpose: Psoriasis is a skin disease that develops following chronic inflammatory signaling and keratinocyte hyperproliferation. The pathogenesis of psoriasis is compound and not yet fully understood. Several studies concerning gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. This study aims to highlight the latest scientific evidence regarding the gut microbiome alterations of psoriatic patients, as well as the state of knowledge in terms of microbiome-targeted therapies as promising preventive and therapeutic tools for psoriasis. Brief description of the state of knowledge: The current state of knowledge indicates that the main causes of psoriasis may be a genetic predisposition, as well as many immunological and environmental factors, including dysbiosis of the intestinal microflora. The article covers clinical and experimental studies which indicate that gut microbiota dysbiosis concerning diversity as well as the composition of the microbiome is the potential causal factor of psoriasis and the gut microbiota may serve as a promising prevention/therapy target for psoriasis patients. Conclusions: This review highlighted a strong link between psoriasis and the gut microbiota, to add new knowledge for discovering the relationship between the altered intestinal microbiota in psoriasis patients. Despite all of these interesting findings, there are a lot of limitations and challenges that future studies should face. More precise and greater studies need to be done to fully understand the potential of microbiota-aimed therapies.

Introduction: Attention-deficit hyperactivity disorder (ADHD) for many years has been thought to occur mainly in the male population. However, recent studies and change in professionals' perception allowed us to understand that there are significant differences between predominant features related to the gender of the affected person, which changes our look at how the condition may exhibit in women.  Current state of knowledge: In this review, we provide a general look at the disorder, its characteristics in the young and adult population, differences in symptoms and finally -  how it may prove difficult to diagnose this condition among women. Several factors that could contribute to development of ADHD were listed in literature, among them genetics, prenatal period, diet and parents’ emotional wellbeing. Concerning women, they are considered to internalize their psychological struggles, such as depression and stress more often than men, rendering them more susceptible toward suicidal behaviors and making diagnosis harder. Conclusions: When it comes to diagnosis in women, the main difficulty is that the symptoms are presented in a different way compared to men suffering from the same disorder. Because of those reasons, it’s harder to make a proper diagnosis. Therefore, further studies, taking account of affected one’s gender needs to be conducted, while medical professionals have to be more cautious.

Introduction and purpose: Light is one of the defining features of life on the Earth, allowing certain biological processes to be subordinated to its presence and absence. With the introduction of artificial light, the human natural biological clock was dysregulated. Apart from that, the studies showed a connection between exposure to artificial light at night (ALAN) and carcinogenesis. The aim of this review was to present currently available knowledge in the online database PubMed about Association Between Artificial Light at Night and Breast and Prostate Cancer Risk Brief description of the state of knowledge: The article covers clinical and population-based control studies which indicate to ALAN exposure can lead to increased incidence of breast and prostate cancer by disruption of circadian rhythms in several mechanisms involving suppression of melatonin production, dysregulation of sleep–activity pattern and disruption of circadian genes. Conclusions: The review support an assumption that breast and prostate cancer incidence is a consequence of ALAN exposure. Further studies should clarify the relationship between ALAN exposure and other types of cancer. Besides, ALAN exposure levels should be measured more precisely than by satellite pictures analysis to reliably conduct studies proving the relation between ALAN exposure and risk of cancer development.