Introduction and purpose: Wound healing is a process including complex overlapping stages requiring many components. Adipose tissue is an organ that is responsible for maintaining homeostasis through inflammatory responses, signal transmission, energy expenditure connected with different organs. Fat tissue is a rich and readily available source of multipotent stem cells. Adipose-derived stem cells (ADSCs) have the potential in tissue regeneration because of their self-renewal and ability to differentiate in various types of cells. This review discusses ADSCs in terms of basic knowledge, methods of acquisition, prospects for use in healthcare, focusing mainly on the potential application in the wound healing process. Brief description of the state of knowledge: The article contains current knowledge about biology, specific properties of adipose-derived stem cells and also shows the relationship to the wound healing process. The review presents research that points to the possibility of using ADSCs in future medicine. Conclusions: Adipose-derived stem cells may constitute a prominent role in tissue regeneration owing to the secretion of various cytokines, the ability to differentiate into multiple lineages, their immunomodulatory effects, and the ease of cell obtaining. Further studies are required to explore the accurate mechanism of ADSCs action and their long-term safety in clinical application. Stem cell therapy brings new hope for the repair of chronic and refractory wounds and skin defects.

Introduction and purpose: Psoriasis is a skin disease that develops following chronic inflammatory signaling and keratinocyte hyperproliferation. The pathogenesis of psoriasis is compound and not yet fully understood. Several studies concerning gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. This study aims to highlight the latest scientific evidence regarding the gut microbiome alterations of psoriatic patients, as well as the state of knowledge in terms of microbiome-targeted therapies as promising preventive and therapeutic tools for psoriasis. Brief description of the state of knowledge: The current state of knowledge indicates that the main causes of psoriasis may be a genetic predisposition, as well as many immunological and environmental factors, including dysbiosis of the intestinal microflora. The article covers clinical and experimental studies which indicate that gut microbiota dysbiosis concerning diversity as well as the composition of the microbiome is the potential causal factor of psoriasis and the gut microbiota may serve as a promising prevention/therapy target for psoriasis patients. Conclusions: This review highlighted a strong link between psoriasis and the gut microbiota, to add new knowledge for discovering the relationship between the altered intestinal microbiota in psoriasis patients. Despite all of these interesting findings, there are a lot of limitations and challenges that future studies should face. More precise and greater studies need to be done to fully understand the potential of microbiota-aimed therapies.

Introduction and purpose: Sepsis is defined by the Sepsis-3 definition as life-threatening organ dysfunction caused by a dysregulated host response to infection1. Common manifestations of sepsis are fever, tachycardia, tachypnoea, confusion, hemodynamic dysfunction, and worsening of tissue perfusion. Sepsis may cause septic shock. The immune system produces reactive oxygen species which can also have an adverse influence on vasoconstruction5. There is a decrease in vitamin C levels in the plasma of patients with multiple organ failure6. Vitamin C plays a role in the synthesis of catecholamines and has antioxidant properties. The usage of vitamin C in sepsis patients has been arousing expectations for many years. Brief description of the state of knowledge: The current state of knowledge indicates that there is no beneficent effect of ascorbic acid on the population which suffered from sepsis. What is more, there is some proof that administrating that vitamin can be noxious and factor into brain functions19. There are also suggestions that it could increase mortality8. Conclusions: Recent studies do not recommend ascorbic acid as a treatment for sepsis. There is not out of the question that in some subpopulations due to pathogens or failed organs administrating vitamin C would benefit. Further research on this topic needs to be followed up.