Partial-thickness cutaneous injuries distributed over exposed body locations, such as the face and extremities, pose a significant risk of infection, function loss, and extensive scarring. These injuries commonly result from impact of kinetic debris from industrial accidents or blast weaponry such as improvised explosive devices. However, the quantitative connections between partial-thickness injuries and debris attributes (kinetic energy, shape, orientation, etc.) remain unknown, with little means to predict damage processes or design protection. Here we quantitatively characterize damage in near-live human skin after impact by debris-simulating kinetic projectiles at differing impact angles and energies. Impact events are monitored using high-speed and quantitative imaging to visualize skin injuries. These findings are utilized to develop a highly predictive, dynamic computational skin-injury model. Results provide quantitative insights revealing how the dermal-epidermal junction controls more severe wound processes. Findings can illuminate expected wound severity and morbidity risks to inform clinical treatment, and assess effectiveness of emerging personal protective equipment.