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Research question: This study sought to answer the following research question: What are the significant determinants influencing online users' attitudes to sports websites? Specifically, this investigation examined (1) the direct and indirect effects of web content and perceived interactivity and (2) the moderating effect of web organization on attitudes.Research methods: Respondents (N = 329) from a large university in the USA were utilized to test a conceptual model in this study. Structural Equation Model (SEM) analysis was used to test four research hypotheses. Results and findings: The results showed that two web content components, entertainment (β = .31, p < .01) and information (β = .22, p < .01), directly influenced the users' attitude toward sport websites, while perceived interactivity directly (β = .28, p < .01) and indirectly (perceived interactivity → entertainment; β = .28, p < .01; perceived interactivity → information; β = .30, p < .01) affected to the attitudes. In addition, web organization played a moderate role between perceived interactivity and users' attitude toward sport websites. Implications: The findings of this study suggest that sport marketers need to place more emphasis on perceived interactivity and web organization, which significantly affect overall attitudes toward their affiliated websites. It would be particularly beneficial for sport marketers to use the interactive content of sport websites to reach current and potential users, but it is important to note that for the interactivity functions to be effective they should be well organized.

To determine P-and S-wave velocities, elastic properties and subglacial topography of the polythermal Fourcade Glacier, surface seismic and radar surveys were conducted along a 470-m profile in November 2006. P-and S-wave velocity structures were determined by travel-time tomography and inversion of Rayleigh wave dispersion curves, respectively. The average P-and S-wave velocities of ice are 3466 and 1839 m s -1 , respectively. Radar velocities were obtained by migration velocity analysis of 112 diffraction events. An estimate of 920 kg m -3 for the bulk density of wet ice corresponds to water contents of 5.1 and 3.2%, which were derived from the average P-wave and radar velocities, respectively. Using this density and the average P-and S-wave velocities, we estimate that the corresponding incompressibility and rigidity of the ice are 6.925 and 3.119 GPa, respectively. Synergistic interpretation of the radar profile and P-and S-wave velocities indicates the presence of a fracture zone above a subglacial high. Here, the P-and S-wave velocities are approximately 5 and 3% less than in the ice above a subglacial valley, respectively. The S-wave velocities indicate that warmer and less rigid ice underlies 10-15 m of colder ice near the surface of the glacier. Such layering is characteristic of polythermal glaciers. As a relatively simple non-invasive approach, integration of P-wave tomography, Rayleigh wave inversion and ground-towed radar is effective for various glaciological studies, including the elastic properties of englacial and subglacial materials, cold/warm ice interfaces, topography of a glacier bed and location of fracture zones.

Background: Cabozantinib, a multiple kinase inhibitor, was recently approved for patients with previously treated unresectable hepatocellular carcinoma (uHCC). We investigated the real-world safety and efficacy profiles of cabozantinib. Methods: This multicenter retrospective study included 110 patients with uHCC who received cabozantinib after progression on other systemic treatments between October 2019 and May 2021. Results: The median age was 58 (range, 20–77) years, and 98 (89.1%) were male. Prior to cabozantinib, all patients were treated with other systemic therapies: sorafenib ( n = 104, 94.5%) and regorafenib ( n = 91, 82.7%) were the most commonly used agents. Immune checkpoint inhibitors were previously used in 93 patients (84.5%). Cabozantinib was used beyond the third-line of therapy in most patients ( n = 90, 81.8%). With a median follow-up duration of 11.9 months [95% confidence interval (CI), 10.8–17.2], the median progression-free survival (PFS) was 3.7 months (95% CI, 3.1–4.9), and the median overall survival (OS) was 7.5 months (95% CI, 5.5–9.5). The disease control rate and overall response rate (ORR) were 66.3% and 3.6%, respectively. In the Child–Pugh A cohort ( n = 88), the ORR was 4.5%, and the median PFS and OS were 4.3 months (95% CI, 3.6–5.8) and 9.0 months (95% CI, 7.5–11.7), respectively. Conclusion: Cabozantinib showed consistent efficacy outcomes with a prior phase III trial, although in this study, it was used as later-line therapy for patients who were refractory to multiple systemic treatments, including immune checkpoint inhibitors.

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