Oxytocin (OT) has an important role in bond formation and social reciprocity, and animal studies indicate that OT functioning is transferred from parent to child through patterns of parental care. Perspectives on attachment suggest that the individual's various attachment bonds are underpinned by the oxytocinergic system. However, prospective human studies that demonstrate the cross-generation transfer of OT as mediated by early caregiving and its impact on children's multiple attachments are lacking. To address these concerns, the current study included 160 mothers and fathers and their firstborn child who participated in a 3-year longitudinal study. At the first and sixth postpartum months, parents' plasma OT was assayed, parent-infant interactions were videotaped and micro-coded, and allelic variations on the OXTR(rs2254298, rs1042778) and CD38rs3796863 genes were measured. At 3 years, parents' and child's salivary OT was assessed and children's social reciprocity observed during interactions with mother, father, and their first best friend. Parents' OT levels were individually stable across the 3-year period, correlated with low-risk OXTR and CD38 alleles, and predicted child OT. Child's social reciprocity with friend was associated with child OT levels, mother's OT-related genes and hormones, and mother-child reciprocity, but not with father's genes, hormones, or behavior. A cross-generation gene-by-environment effect emerged, with low child OT levels predicted by the interaction of maternal high-risk CD38 allele and diminished maternal care in infancy. These results demonstrate individual stability in peripheral OT across several years and describe a cross-generation transfer of OT through caregiving in humans within a prospective longitudinal design. Consistent with other mammals, biobehavioral experiences within the parent-infant bond shape children's affiliative biology and social behavior across multiple attachments. Our findings bear important implications for conditions involving disruptions to maternal-infant bonding and underscore the potential for peer-based interventions.

Adolescents' participation in intergroup conflicts comprises an imminent global risk, and understanding its neural underpinnings may open new perspectives. We assessed Jewish-Israeli and Arab-Palestinian adolescents for brain response to the pain of ingroup/outgroup protagonists using magnetoencephalography (MEG), one-on-one positive and conflictual interactions with an outgroup member, attitudes toward the regional conflict, and oxytocin levels. A neural marker of ingroup bias emerged, expressed via alpha modulations in the somatosensory cortex (S1) that characterized an automatic response to the pain of all protagonists followed by rebound/ enhancement to ingroup pain only. Adolescents' hostile social interactions with outgroup members and uncompromising attitudes toward the conflict influenced this neural marker. Furthermore, higher oxytocin levels in the Jewish-Israeli majority and tighter brain-to-brain synchrony among group members in the Arab-Palestinian minority enhanced the neural ingroup bias. Findings suggest that in cases of intractable intergroup conflict, top-down control mechanisms may block the brain's evolutionary-ancient resonance to outgroup pain, pinpointing adolescents' interpersonal and sociocognitive processes as potential targets for intervention.intergroup conflict | empathy | alpha oscillations | oxytocin | brain-to-brain synchrony

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The rapid increase in terror-related activities, shift of battlefield into civilian locations, and participation of youth in acts of violence underscore the need to find novel frameworks for youth interventions. Building on the Israeli-Palestinian conflict and social neuroscience models we developed an eight-week dialogue group-intervention for youth growing up amidst intractable conflict. Eighty-eight Israeli-Jewish and Arab-Palestinian adolescents (16-18years) were randomly assigned to intervention or control groups. Before (T1) and after (T2) intervention, one-on-one conflict interaction with outgroup member were videotaped, oxytocin levels assayed, attitudes self-reported, and youth interviewed regarding national conflict. We tested the hypothesis that dialogue intervention would enhance empathic behavior and increase oxytocin levels following interaction with outgroup member. Intervention increased youth perspective-taking on national conflict. Oxytocin increased from T1 to T2 only for adolescents undergoing intervention who improved perspective taking in the process. Structural equation modelling charted three pathways to behavioral empathy toward outgroup member at T2; via endogenous oxytocin, empathic cognitions, and dialogue intervention; however, an alternative model without the intervention arm was non-significant. Our findings highlight the important role of empathy in programs for inter-group reconciliation and support evolutionary models on the precarious balance between the neurobiology of affiliation and the neurobiology of outgroup derogation.

Intergroup bias is a ubiquitous socio-cognitive phenomenon that, while sustaining human dependence on group living, often leads to prejudice, inequity, and violence; yet, its neural underpinnings remain unclear. Framed within the Israeli-Palestinian conflict and targeting youth, this study utilized magnetoencephalography to describe intrinsic neural oscillatory processes that represent the intergroup bias and may link with engagement in peacemaking in order to shed further light on the neural mechanisms underpinning intergroup conflict. Across the oscillatory spectrum, from very low to very high frequency bands, the only rhythm found to underlie the intergroup bias was the alpha rhythm. Alpha was continuously activated across the task and integrated a rapid perceptual component in occipital cortex with a top-down cognitive-control component in medial cingulate cortex. These components were distinctly associated with real-life intergroup dialog style and expressed attitudes that promote active engagement in peacemaking. Our findings suggest that the cortical alpha rhythm plays a crucial role in sustaining intergroup bias and address its impact on concrete intergroup experiences. Results highlight the need to provide opportunities for active peace-building dialog to youth reared amidst intractable conflicts.