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LYMPHOGRANULOMA VENEREUM IN YOLK-SACcompound in human subjects confirm these observations. In Table 111 are presented data bearing upon the excretion of sulfathiazole in the urine of human beings. At once, one is struck by the fact that in comparison with sulfapyridine, definitely less of the excreted sulfathiazole is present in the conjugated form. It is also interesting that che excretion of this compound, following a single oral dose, is generally complete within 24 hours, and that following such a dose, from 80% to 90% of the drug was recovered in the urine, thus denoting that the absorption of sulfathiazole under conditions of the test, was much more complete than one would expect had the subject been given sulfapyridine.Conclusions. It has been shown that the acute toxicity of sulfathiazole (as measured by the parenteral injection of sodium salts) for mice is one-third greater than that of sulfanilamide, and about half that of sulfapyridine, sulfathiazole methyl and sulfathiazole phenyl. Sulfathiazole is absorbed more readily and is excreted more rapidly than is sulfapyridine. Because of its rate of excretion it is probable that doses of sulfathiazole spaced at intervals of 4 hours will maintain adequate concentrations of the drug in the blood of patients.We wish to thank E. R. Squibb and Son and the Calco Division of the American Cyanamid Company for supplying us with sulfathiazole, and the Department of Medical Research of the Winthrop Chemical Company, Inc., for supplying the sulfathiazole methyl and the sodium salt of sulfathiazole phenyl.In the course of cheniotherapeutic studies, experiments were performed with a strain of the agent of lymphogranuloma venereum* in which passage-mouse brain was used as a source of virus. About one-third of all mice given intracerebrally 0.03 ml of 1 :lo0 dilution died. The L~50' was obtained with a dilution of 1 : 14. Because of * Obtained through the courtesy of Dr. Wm. L. Fleming, the School of Hygiene IReed, L. H., and Mueizch, H., Am.

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