Background: Monochorionic diamniotic (MCDA) twins are at significantly increased risk of perinatal morbidity and mortality due to shared placentation and the presence of inter-twin placental vascular anastomoses. Aim of the work: The main aim of this study was to validate first trimester ultrasound screening for twin-to-twin transfusion syndrome (TTTS) and selective intrauterine growth restriction (sIUGR) in monochorionic twin pregnancies using the triad of nuchal translucency (NT), cord insertion site and inter-twin discordance in fetal size. Summary: We have demonstrated that NT and CRL were significantly higher in TTTS group than sIUGR group. And difference in NT, CRL and cord insertion site was identified as predictive markers for sIUGR and TTTS.

Background: Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine and metabolic conditions in premenopausal women. Objectives: The goal of this study was to see the efficacy of Letrozole in conjunction with clomiphene citrate versus Letrozole alone in inducing ovulation in PCOS patients. Patients and methods: This was a randomized clinical trial (RCT) done on a total of 200 patients who came to South Valley University, Obstetrics and Gynecology clinics, after receiving the ethical committee permission and signed informed consent from all participants.Results: Regarding all treatment outcomes, there were no statistically substantial difference among the two groups as regards the following parameters: ovulation, mature follicle number, endometrial thickness, OHSS, single pregnancy, clinical pregnancy, multiple pregnancy and miscarriage, P>0.05. Conclusion: this research showed that in terms of infertility therapy in women with PCOS, the combination of letrozole and CC was linked to"Although there is absolute difference between the two groups in favor of the combined use of letrozole plus clomiphene citrate, this difference is not statistically significant". These new findings indicate that this combined therapy might be a low-risk, low-cost infertility treatments.

Background: Missed Abortion is non-viable intrauterine pregnancy with either an empty gestational sac or a gestational sac contains an embryo without fetal heart activity. Objectives: The aim of this study was to compare effect of misoprostol with clomiphene citrate, misoprostol with letrozole and misoprostol alone in terminating first trimester missed abortion. Patients and methods: This randomized clinical trial was included patients with missed abortion attending to our outpatient clinic at