This study describes dynamic uptake of antibiotic drug diclofenac sodium from aqueous solution using polyaniline as sorbent. The sorbent polyaniline was prepared by oxidative polymerization of aniline and characterized by FTIR spectrum analysis and TGA. The optimum sorbent/sorbate mg/mL ratio and pH range for maximum drug uptake have been found to be 2.0 and 5.5 to 10.5, respectively. Out of various kinetic models applied, the pseudo second-order kinetic equation has been found to fit well on the kinetic uptake data. The pseudo second-order rate constants for adsorption have been found to be 0.982 Â 10 À2 , 7.24 Â 10 À2 , and 18.09 Â 10 À2 min À1 mg À1 g for drug solutions with initial concentrations of 10, 20, and 30 mg L À1 , respectively. The overall sorption process has been found to be governed by intraparticle diffusion.The sorptive removal of drug from aqueous solution has also resulted in enhancement in bacterial growth of Escherichia coli.

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The novel coronavirus COVID-19 has caused a global pandemic with many long-ranging effects on the physiological balance of the human body. The impact of COVID-19 on the thyroid axis remains uncertain. Our aim was to assess the long-term consequences of COVID-19 infection and its vaccination with thyroid hormones. Thirty laboratory-confirmed COVID-19-positive patients with no vaccination record, thirty COVID-19-negative patients with vaccination records, and ten healthy subjects were retrospectively, and cross-sectionally enrolled in this study. An ELISA assay was performed to evaluate thyroid function tests, including the total triiodothyronine (TT3), total thyroxine (TT4), and thyroid stimulating hormone (TSH). We found decreased levels of TT3, average or low plasma T4 levels, and standard or slightly decreased TSH levels in unvaccinated COVID-19-positive patients than in the healthy group, while the vaccinated COVID-19-negative group had normal thyroid hormone levels compared to controls. The correlation between TT3 and TSH levels gradually shifted from no association to a negative pattern in the unvaccinated COVID-19-positive group. Again, a highly significant negative correlation between TSH and TT3 was observed on days above 150, although a slight fluctuation was noted on day 90. This pilot study from Bangladesh shows that abnormalities in thyroid function can be observed during COVID-19 infection and after vaccination, which gradually recovers over time.

In this study, chitin (CT) has been used as a potential sorbent for the removal of antibiotic drug Gatifloxacin (GF) from aqueous solutions using batch experiments. The equilibrium drug uptake was studied as a function of sorbent dose, pH of sorbate solution and temperature. The experimental data was analyzed using Langmuir, Freundlich and Temkin isotherm models. It was found that to some extent, all the models showed their suitability. The equilibrium sorption capacity obtained at 18, 28 and 37 o C was 97.108 ± 2.35, 100.0 ± 3.23 and 181.818 ± 5.58 mg g -1 respectively. The optimum uptake was found to be in the drug solution with pH value of nearly 6.0. The thermodynamic parameters, free energy change (G o indicated that drug uptake process was spontaneous and endothermic in nature respectively. The mean sorption energy E, as determined using Dubinin-Radushkevich (D-R) isotherm model, was found to be 7.424 ± 0.03 kJ mol -1 thus, indicating physical sorption process. Finally, the sorption of drug was also confirmed by antimicrobial test.

Background: Stearoyl-CoA desaturase 1 (SCD1) activity, a key lipid metabolism regulator, may impact type 2 diabetes (T2D). Previously, we reported a significant functional interaction between SCD1 and T2D in the Bangladeshi population. In the present study, we investigated the relationship between the SCD1 rs7849 polymorphism and T2D risk variables (n = 90; mean age, 45 y; range, 30–70 y). Methods: 45 T2D patients and 45 healthy controls were recruited. Demographic and anthropometric data of the subjects were recorded and biochemical parameters were measured following standard protocols. Genomic blood DNA was extracted by PCR-RFLP method to identify the SCD1 gene rs7849 polymorphic variant and Hardy-Weinberg Equilibrium for SCD1 gene variants was tested. Results: The results showed that the heterozygous allele (TC) for SCD1 at position 7849 has been associated with higher postprandial blood glucose levels (p-value < 0.05). Healthy non-diabetic individuals with the SCD1 rs7849 variant had higher BMIs than their diabetic counterparts (p-value < 0.05). Females with rs7849 heterozygous variants had significantly higher body composition and body fat distribution when compared between the genders (p-value < 0.05). Conclusions: This preliminary research from Bangladesh raises the possibility that genetic variations in the SCD1 gene may affect the propensity to type 2 diabetes.