The regulation of the interrenal of teleostean fishes is reviewed from the perspective of non-classical control mechanisms and new evidence is presented suggesting gonadotropic control of the interrenal. Cortisol secretion by the interrenal, in addition to regulation by ACTH, appears to be mediated by other hormones. Physiologically relevant, direct control of interrenal function by hydromineral factors is unclear.In vitro experiments with interrenals of coho salmon (Oncorhynchus kisutch) indicate that salmon gonadotropin is extremely corticotropic and both ACTH and gonadotropin stimulate the secretion of large quantities of androstenedione from the interrenal.