4‐(4′‐metoxy‐2‐Benzothiazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 4a, 4‐(6′‐nitro‐2‐Benzothiazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 4b, 4‐(6′‐fluoro‐2‐Benzothiazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 4c and substitued 4‐(1,2,4‐triazolyl‐3‐amino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐ones 4(d‐e) are synthetized by condensation of 4‐Chlor‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 2 and corresponding heteroarylamines 3(a–e) under the reflux reaction conditions. Alkali hydrolysis of 4(a–e) afforded the 2‐hydroxy‐ù‐nitroacetophenone 5. Microbiological activity of products 4(a–d) are investigated and results are submitted for their activities against Staphylococcus aureus, Escherichia coli and Clebsiella.

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Nowel benzothiazol‐2‐yl‐benzylidene imines are synthesized by condensation of benzaldehydes and corresponding 2‐aminobenzothiazoles. Condensation of benzaldehyde 1a and 2‐aminobenzothiazoles 2(a,b) gave benzothiazol‐2‐yl‐benzylidene imines 3(a,b). By condensation of 3‐nitrobenzaldehyde 1b and 2‐aminobenzothiazoles 3(a,b) , corresponding benzothiazol‐yl‐3‐nitrobenzylidene imines 3(c, d) were synthesized. The antibacterial activity of products 4(a‐d) were investigated and results were submitted for their activities against E. coli, Clebsiella and S. aureus. Compound 3d showed light bactericide activity against S. aureus. Emphatic activity against E. coli exhibited compounds 3d and 3c , whereas 3d and 3b exhibited the strongest activity against Clebsiella. In general there was a direct positive correlation between increasing concentration of the compound and antibacterial activity.

4‐Benzothiazolylamino‐6‐methyl‐2H[1]‐pyran‐2‐one 6a , 4‐(4‐Methylbenzothiazolylamino)‐6‐methyl‐2H[1]‐pyran‐2‐one 6b , 4‐(5,6‐dimethylbenzothiazolylamino)‐6‐methyl‐2H[1]‐pyran‐2‐one 6c and substituted 4‐(Benzothiazolylamino)‐6‐methyl‐3‐nitro‐2H[1]‐pyran‐2‐ones 6(d, e) are synthesized by condensation of 4‐Chlor‐6 methylpyran‐2‐ones (2, 4) and corresponding benzithiazolylamines 5(a‐e) under reflux reaction conditions. The antibacterial activity of products 4(a‐d) against Staphylococcus aureus, Clebsiella and Escherichia coli were investigated. Compounds 6(a‐e) showed light bactericide activity against Staphylococcus aureus, Escherichia coli and Clebsiella. Compounds 6e and 6c were more active against Staphylococcus aureus. Compounds 6d and 6b exhibited the strongest activity against Clebsiella, whereas 6e was more active against Escherichia coli. In general there was a driect positive correlation between increasing concentration of the compound and anitbacterial activity.

Some new Pyrimidin‐2‐yl‐benzylidene‐imines are synthesized by catalytic reactions of aromatic aldehydes and corresponding 2‐Aminopyrimidines. Condensation of Benzaldehyde 1a and 2‐Aminopyrimidines 2(a,b) gave pyrimidin‐2‐yl‐benzylidene imines 3(a,b). By condensation of salycilaldehyde 1b and 2‐Aminopyridines 2(a,b), corresponding 2‐[(pyrimidin‐ylimino)‐methyl]‐phenoles 3(c,d) were synthesized. The antibacterial activity of products 3(a–d) were investigated and results were submitted for their activities against Escherichia coli, Clebsiella and Staphylococcus aureus.Compound 3a showed emphatic bactericide activity against Staphylococcus aureus. Compounds were more active against. Light activity against Escherichia coli exhibited compounds 3a and 3c, whereas 3d exhibited the strongest activity against Clebsiella. In general there was a direct positive correlation between increasing concentration of the compound and antibacterial activity