Guava (Psidium guajava) encompasses a broad range of nutritional and therapeutic potential. Depending on the species, the fruits are 4-12 cm long and have a round or oval form. It belongs to the Myrtaceous family and mostly cultivated in tropical and subtropical climates of subcontinent including Pakistan, India and Bangladesh. The most therapeutic value could be traced in pink form of guava. The phytochemicals "quercetin, avicularin, apigenin, guaijaverin, kaempferol, hyperin, myricetin, gallic acid, catechin, epicatechin, chlorogenic acid, epigallocatechin gallate, and caffeic acid" have been investigated in the guava plant leaves for its therapeutic properties. Antidiarrheal, antihypertensive, antilipidemic, anticancer, and other health promoting benefits are associated in both of the fruits and the leaves of guava. The nutritional and phytochemical profiles of guava leaves are presented in detail in current review. Many bioactivities of guava leaf extracts are also critically investigated. Guava leaves might be employed as a component in of nutraceutical and medications due to their phytochemical profile. To prove the efficacy of the guava leaf extracts, further extensive clinical trials are needed.

Objective: The researchers wanted to see how cytotoxic, phenolic, and antioxidant potential of Euphorbia nerrifolia were. Methods: The organic extracts were obtained by extraction of whole dried plant with n-hexane, dichloromethane and methanol. Phyto-chemical screening was carried out by using standard methods. Total phenolics contents were measured by using the Folin-CioEcalteu reagent method. Cytotoxic action was evaluated by brine shrimp lethality bioassay. DPPH radical assay was employed for antioxidant activity. Results: Phytochemical investigations confirmed the presence of anthraquinones, saponins, cardiac glycosides and flavonoids. Highest phenolic content (276.41 ± 64 mg GAE/g dry extract wt) was observed in methanol extract. Significant antioxidant potential was exhibited by methanol extract by means of 78.8% inhibition with IC50 value of 35.71µg/ml). In brine shrimp lethality bioassay, methanol extract demonstrated prominent cytotoxicity at highest level of dose with LD50 471.05. Conclusion: The study concluded that Euphorbia nerrifolia contains significant antioxidant and cytotoxic potential. Further investigation is suggested for isolation of secondary metabolites responsible for reported biological activities.

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