Pesticides have a negative impact not only on the environment but also on human health. Therefore, alternative method of integrated pest management (IPM) is a suitable technique used to control insect pest and to protect the environment for the betterment of human health. It is a combination of biological, chemical, cultural and mechanical methods. All these methods are essentially integrated with each other. The purpose of the study was to identify the residual impact of pesticides on environment and health of sugarcane farmers; with special reference to integrated pest management. The study was conducted in District Rahim Yar Khan was taken randomly as a universe of the study from the province of Punjab. Tehsil Sadiqabd was selected randomly from District Rahim Yar Khan. Out of twenty-nine rural Union Councils (RUCs) of Tehsil Sadiqabad, two RUCs were selected purposively due to high production of sugarcane. From each selected Union Council, two villages were selected into account to investigate the health-related issues of sugarcane growers and its holistic effects on environment. A pre-tested and well-structured interview schedule was developed for the collection of information from sugarcane farmers. Data were analyzed using both descriptive and inferential statistics through the Statistical Package for Social Sciences. The results indicated that various diseases were present among sugarcane workers due to residual impact of pesticides. The diseases were skin burning, skin infection, nausea, chest pain, diarrhea, respiratory problems, hypertension, convulsion, bleeding, cramping, nausea, asthma, fever, dizziness and vomiting. It also indicated that pesticides affects the natural enemies of sugarcane, physical structure of soil, climatic condition, increase resistant in sugarcane pests and cause environmental pollution. The results revealed that the majority of the respondents were unable to practice IPM due to lack of technical knowledge, practical skills and awareness related to the identification of sugarcane pest and their management. Results indicated that IPM technology is a source of reduction of pesticides, protect environment and human health. The study recommended that awareness regarding integrated pest management should be promoted through proper campaigns to overcome the blind use of pesticides for mitigation insect pest of sugarcane.