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Original Scientific ArticleMac Vet Rev 2016; 39 (1): 77-81The objective of this study was to determine the physiological effects of detomidine on Pateri goats. A total of six female Pateri goats were randomly treated with three different dose rates of Detomidine at 40 μg, 50 μg and 60 μg/kg body weights. The effects of Detomidine on respiratory and heart rate, rectal temperature and serum glucose level were investigated. Following detomidine intravenous administration in goats, it produced dose dependent effect on physiological parameters. Respiratory and heart rate decreased after intravenous administration in all goats. The heart rate decreased at 5 min with all dose rates and returned to the base line at 60 min. This change in heart rate was dose dependent and there was no significant (P>0.05) change observed with 40 μg and 50 μg/kg of Detomidine. However, there was significant difference (P<0.05) at 75 min between the 40 μg and 60 μg/kg of Detomidine in all goats. However, significant (P<0.01) increase in serum glucose level occurred with all dose rates at 30 min compared with control groups. It is concluded that Detomidine has produced no adverse effect on physiological parameters.

A 62-year-old woman presented with a skin-coloured indurated asymptomatic plaque, 150 mm in diameter on the knee. Histological analysis of a skin biopsy taken from the lesion showed haphazardly arranged bundles of smooth muscle in the deep dermis, characteristic of a pilar leiomyoma. Cutaneous pilar leiomyomas are rare, benign smooth muscle tumours arising from the arrector pili muscle, which usually appear as red or brown papules < 15 mm in diameter. This case is unusual in its clinical appearance and size, being at least 10 times larger than the largest previously documented cutaneous pilar leiomyoma. Similar lesions have also been previously reported under the term 'acquired smooth muscle hamartoma' (ASMH). These cases are also rare and have no known consistent clinical features. Histologically it is difficult to differentiate between ASMH and leiomyomas, and some authors would consider this case as a new report of ASMH. We feel, however, that as the lesion is composed of only one element and has grown out of proportion with the growth of the limb, it is more in keeping with a true tumour rather than a hamartoma. We suggest the term 'diffuse pilar leiomyoma' may be more appropriate in this case, representing a new clinical variant of cutaneous pilar leiomyoma.

The study was carried out to determine the histological characterizations of wound healing in cats. For the purpose, 24 feral/stray with mean age of 7 to 33 months and body weight between 1.72 to 4.02 kg cats were selected and divided in 4 subgroups. Ovariohysterectomy was performed in all the cats. The cats operated through flank approach healed earlier and histological characterization showed better wound healing through flank in adult cats. All the cats did not heal on the 12th day, and the trend of healing showed bit maturation. Parameters studied are histological characterization of wound healing were acute inflammation, chronic inflammation, granulation tissue amount, granulation tissue amount and fibroblast maturation, collagen deposition, re-epithelization and neovascularization.

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