Dyslipidemia is a condition of the lipid profile in the blood at an abnormal level. Based on the 2013 Riskesdas, about 35.9% of the Indonesian population aged >14 years experienced dyslipidemia. Black cumin is an herbal plant that through its antioxidant activity can cure diseases such as dyslipidemia. Meanwhile, garlic is known to contain active substances that can play a role in helping the process of increasing lipid profile levels in the body. Some studies have examined the potential combination of these two compounds' usage in pathological conditions and yielded significant results. Therefore, this literature study was compiled to expand and summarize the analysis of the combination of black cumin and garlic potential as an alternative therapeutic modality in dyslipidemia. The writing of this paper uses a literature review study method. References are obtained from globally published journals that can be accessed through the International Library of Medicine (Pubmed), Clinical key, and PlosOne with a search time range from September 26-October 26, 2020. Based on the analysis process in this literature review, we conclude that the combination of the two compounds has also been shown to strengthen the antioxidant activity that can be given. So that the combination of Nigella sativa and Allium sativum can be used as a modality of herbal therapy in cases of dyslipidemia.

Induction by high-fat diet (HFD) is frequently performed for research on hypercholesterolemia in experimental animals. In general, HFD is obtained by combining various components, but only few studies have investigated the potential of each component to induce hypercholesterolemia in experimental animals. This study aimed to identify the potential of a number of HFD components found on a day-to-day basis in society for induction of hypercholesterolemia in animal models. The research involved a posttest only group design conducted on 30 Rattus norvegicus rats for 28 days. In addition to receiving standard ad-libitum feed, the rats were given appropriate treatment according to the group, each at a dose of 1ml/100gBW for P1 = distilled water, P2 = chicken egg yolk, P3 = quail egg yolk, P4 = duck egg yolk, P5 = liquid butter, and P6 = liquid margarine. The lipid profile (total cholesterol, LDL, HDL, triglycerides) was examined at the end of the study. The obtained blood serum was examined using a spectrophotometry to yield the lipid profile data. The atherogenic index (AI) was measured by dividing LDL by HDL. The data were analyzed using a one-way ANOVA. This study showed that induction by duck egg yolk for 28 days resulted in the highest levels of total cholesterol, LDL, HDL, and AI (P4; total cholesterol = 85.00 ± 22.86, LDL = 23.20 ± 9.05, HDL = 37.16 ± 12.21, AI = 0.63 ± 0.12). The induction by liquid margarine was able to result in the highest increase in the triglyceride level compared to the healthy group and other induction of hypercholesterolemia, but there was no difference in the levels of total cholesterol (p = 0.362), LDL (p = 0.112), HDL (p = 0.631), triglycerides (p = 0.427), and AI (0.094). This study shows that duck egg yolk has the potential to be used in induction of hypercholesterolemia in experimental animals..

Changes in the kidneys can lead to increased blood pressure, which can be followed by an increase in cortisol levels. Subtotal nephrectomy is one of the methods to provide animal models of hypertension. The combination of kefir milk and jicama as a synbiotic drink is expected to maintain cortisol under normal levels in hypertensive conditions. Aim: This study aims to determine the effect of kefir and jicama synbiotic beverage on rats' serum cortisol levels after a subtotal nephrectomy procedure. Methods: Male Wistar rats were divided into five groups, i.e. a group of subtotal nephrectomy, sham group, and three synbiotic groups receiving subtotal nephrectomy procedure and synbiotics with differences in composition (Syn 1, Syn 2, and Syn 3). The serum cortisol levels were measured with ELISA after a month of kefir and jicama synbiotic administration. The results were analyzed statistically using one-way ANOVA. Results: The serum cortisol levels (ng/mL) were 165.49