Statement of Novelty. Poultry feed contamination due to mycotoxins is one of the major threats to the growing poultry industry. Surveillance of different mycotoxins, including aflatoxin, is very important to control economic and health hazards associated with these toxins. Studies reporting aflatoxin levels in poultry feed are limited. Therefore, this study was conducted to examine the occurrence of total aflatoxin in poultry feed. This study is the first-ever documentation about the frequency and quantitative estimations of total aflatoxin levels in poultry feed consumed to provide solid feedback to the poultry industrialists and researchers involved in studying the mycotoxins. Objective. Contamination of poultry feed with mycotoxins such as aflatoxin is a major concern for the poultry industry that results in a significant economic loss and directly affects consumers. Monitoring the aflatoxin levels in poultry feed is crucial for controlling economic loss and decreasing the health hazards to the population. This study was conducted to examine the occurrence of total aflatoxin in poultry feed in a high consumption area. Three different poultry feeds, i.e., starter, grower, and finisher, were assessed through continuous sampling from farms. The incidence of positive samples for aflatoxin contamination was 92.5%. Grower feed had the highest frequency (100%) of aflatoxin positive samples and aflatoxin levels with a mean value of 56.34 ppb. Further, the range of moisture content was around 6.8%-10.98%. No significant correlation between humidity and aflatoxin contamination was revealed when analyzed by Pearson’s correlation coefficient with r 2 of 0.05 and p value of 0.13. The results warrant the need for constant monitoring programs for the prevention of aflatoxin contamination in local poultry farms
The present study was designed to investigate effect of Oxalis corniculata (Creeping wood sorrel) against aflatoxicosis in straight run broiler chicken (Hubbard strain). Hundred and twenty-day old broiler chicks were randomly divided into six groups with two replicates. Two different levels of O.corniculata (250; 500 mg/kg b.w) with and without AFB1 (350 ppb) and a control treatment were added to the diet. Dietary treatment initiated at the end of 1 st week and sustained for six weeks. O.corniculata supplementation in the diet during five weeks significantly reduced body weight, cumulative feed intake and feed conversion ratio of the treated groups in dose dependent manner. Dietary incorporation of O.corniculata 250 mg to 500mg induced negative effects on overall broiler health performance. KEYWORDSOxalis corniculate, aflatoxicosis, cumulative feed intake, feed conversion ratio.
Authors' Contribution CY and DP performed the experiments, analyzed the data of the study and wrote the paper. CL, AX and PH collected the samples. HO and HY conceived and designed the experiments.
Introduction: The Rubella virus has worldwide occurrence and congenital Rubella syndrome are widely recognized as emerging infection in several parts of the world. Methodology: We investigated for peptide vaccine with specific T and B-cell epitopes was identified through bioinformatics-based approaches. These were identified utilizing available Rubella virus E1 glycoprotein sequence databases. The outer-membrane glycoprotein, E1 is a target protein for the prediction of best antigens. Results: The bioinformatics online software Bepipred 2 was used for prediction of potential B-cell epitope (pfcntphgqlevqvppdpgd) was identified and it has shown high conversation against E1 glycoprotein and few other bioinformatics online software NetMHCpan, IEDB and NetCTL was used to identify maximum surface-exposed residues. T-Cell epitope (rpvalpral) was identified and shown to be conserved to E1 Glycoprotein. Predicted epitopes were found to had promiscuous class-I major histocompatibility complex binding affinity to major histocompatibility complex super types, antigenicity scores and high proteasomal cleavage. The three-dimensional modelled structures was created using I-TASSER online server for highlighting the predicted T- and B- cell epitopes. Conclusion: The predicted T and B cell epitope could be used for development of immunoglobulin assay and vaccines.
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