The study was conducted during the winter season 2019/2020 at Al-Qurna (Al-Sharesh) which is about 65 kilometers north of the Basra governorate center to study the effect four concentrations of salicylic acid (0, 60, 120, 180 mg L -1 ), and four concentrations of tryptophan acid (0, 60, 120, 180 mg L -1 ), the yield and quality of bread wheat (Buhooth-22 variety). Experiment conducted as a factorial (4 × 4) according to Randomized Complete Block Design (RCBD) with three replicates. The results showed that concentration of120 mg L -1 salicylic achieved the highest number of spikes (603 spikes m -2 ), number of grains spike (44.82 grain spike -1 ), weight of 1000 grain (37.10 g), grain yield (6.12 µg ha -1 ), chlorophyll content in the Flag leaf (475.00 mg m -2 ), grain protein (14.31%), dry gluten (33.03%) and wet gluten (12.99%). Also concentration of 120 mg L -1 tryptophan achieved the highest number of spikes (622 spikes m -2 ), number of grains spike (43.70 grain spike -1 ), grain yield (5.93 µg ha -1 ), chlorophyll content in the Flag leaf (485.30 mg m -2 ) protein in grains (14.78%), dry gluten (34.05%) and wet gluten (13.37%). The interaction was significant; plants that sprayed with S 2 T 2 were superior in all study characteristics. We conclude that it is possible to spray salicylic acid and tryptophan at a concentration of 120 mg L -1 to the wheat crop to improve the yield and quality of wheat grains at the lowest costs and reduce the environmental pollution resulting from the use of a large amount of chemical fertilizers.