Aim: The aim is to identify the chronic endometritis (CE) incidence in recurrent implantation failure (RIF) patients undergoing in vitro fertilization (IVF) treatment and compare the IVF outcomes of RIF patients with CE following antibiotic therapy with RIF patients without CE. Another purpose is to compare the IVF outcomes of described RIF patients with patients undergoing the first cycle of IVF. Methods: In this retrospective cohort study, CE was diagnosed with CD-138 immunohistochemical staining. Among RIF patients, two groups were formed as group 1, including patients diagnosed with CE and treated by antibiotics (n = 129), and group 2, including patients without CE (n = 103). Patients with the first IVF cycle having similar infertility etiologies with RIF patients were reviewed as group 3 (n = 932). Results: CE was diagnosed in 55.6% of RIF patients. The number of oocytes retrieved was not different between groups. Implantation rates (IR) were similar after antibiotic treatment in RIF patients with or without CE. However, Group 3 had a higher IR (41.1%) than group 1 and 2 (23.1% and 30.1%, respectively) (p < 0.001). Clinical pregnancy (CPR) and live birth rates (LBR) were comparable between RIF groups. However, CPR and LBR were significantly higher in group 3 (48.6% and 40.5%) than group 1 (36.4% and 27.9%), and group 2 (37.9% and 30.1%) (p = 0.007 and p = 0.005, respectively). Conclusion: Unidentified endometrial factors except CE may also affect the implantation process, although CE is a frequent finding in patients with RIF. Reproductive outcomes may not be improved only with antibiotics in RIF patients with CE.

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Background/Aim: Anemia is a disease that can be easily treated, but it is still widespread worldwide. Anemia can affect nearly 40% of women. Anemia has been extensively studied and related to a variety of pregnancy complications. The primary purpose of our study was to discover the relationship between preeclampsia and anemia in the first trimester, and the secondary goal was to analyze the outcomes of newborns born to these mothers. Methods: This study was compiled as a retrospective cohort study. Age, gravida, parity, and thyroid stimulating hormone (TSH) levels were recorded in a patient’s first visit file. Hemoglobin counts in the first trimester were analyzed as hemogram values. Those with a hemoglobin value <11 g/dl during pregnancy were classified as anemic. The patients' file records were reviewed to determine mode of delivery, birth weight, and Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) scores. To confirm a diagnosis of preeclampsia, the American Congress of Obstetricians and Gynecologists (ACOG) criteria were used. Results: After the exclusion of 186 women due to comorbidities and multiple pregnancies, 364 women were evaluated. The number of anemic pregnant women in the first trimester was 87 (23.9%), and 277 non-anemic women were matched with the anemic group. No statistical difference between the groups in terms of demographic characteristics, such as age, gravida, body mass index (BMI), and TSH were found. No statistical difference between the groups in terms of delivery type, infant birth weight, and APGAR scores were found (P > 0.05). Preeclampsia frequency was statistically higher in pregnant women who were anemic in the first trimester (P = 0.032). Conclusion: Preeclampsia was found to be more common in pregnant women who were anemic in the first trimester. Although it would seem that neonatal outcomes are unaffected, we believe that the unaffected outcomes are due to iron replacement. To avoid pregnancy complications, it is crucial for women not to be anemic prior to becoming pregnant.

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