Objective: The aim of this study was to compare the complication rates of oocyte pick-up (OPU) procedures via transvaginal ultrasonography in patients with different levels of ovarian reserve. Methods: In total, 789 patients who underwent OPU procedures for in vitro fertilization (IVF) were included in the study.Results: Individuals with normal ovarian reserve had a 2.947-fold higher risk of complications in OPU procedures than individuals with low ovarian reserve, and individuals with high ovarian reserve had a 7.448-fold higher risk of complications than individuals with low ovarian reserve. In addition, a higher number of IVF trials was associated with an increased risk of complications.Conclusion: The results of this study show that OPU has a higher risk of complications, particularly severe pain, in patients with high ovarian reserve. It is thought that complications can be reduced by preferring mild stimulation in patients with high ovarian reserve. Collecting fewer oocytes is also associated with a lower risk of complications from OPU. Even if a patient’s reserve is very good, fewer and higher-quality oocytes should be targeted with the use of the lowest possible dose of drugs.

Aims: To examine the association between thyroid autoimmunity (TAI) and early pregnancy serum beta human chorionic gonadotropin (ß-hCG) levels in spontaneous pregnancy. Methods: In this retrospective case-control study, women between the ages of 20 and 40 were included. The study subjects were 130 women euthyroid and healthy patients with spontaneous pregnancy. Subjects were divided into two groups: those with autoimmune thyroid disease (TAI group; n=60) and those without the disease (control group; n=70). Results: The mean age and body mass index (BMI) of the subjects were 30.22±4.14 years and 24.51±2.04, respectively. The value of anti-thyroid peroxidase antibodies (TPO-Abs) and anti-thyroglobulin antibodies (TG-Abs) in the TAI group is three times twenty times more than the control, respectively. Results found no statistically significant association between between TAI and control groups in regard to hemoglobin, alanine transaminase (ALT), aspartate transaminase (AST), thyroid-stimulating hormone (TSH), platelet (PLT), creatine, free thyroxin (FT4), and blood urea nitrogen (BUN) (p>0.05). There was statistically significant difference between groups in terms of the serum ß-hCG level (p<0.05). Conclusion: In this study, the effects of TAI were significant on early-stage pregnancy serum ß-hCG levels; therefore, thyroid levels should be considered, and proper treatment should be started early.

Aims: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women. Hyperinsulinemia and insulin resistance (IR) are the most important metabolic abnormalities that affect these patients. This study aimed to investigate the variables related to IR in patients with different PCOS phenotypes. Methods: This retrospective study included 389 women diagnosed with PCOS in Bezmialem Hospital between november 2020 and september 2022. Information about patients was collected through their electronic records. PCOS was diagnosed based on the Rotterdam criteria, and four phenotypes of A (oligoovulation+ hyperandrogenism+PCO), B (oligoovulation+hyperandrogenism), C (hyperandrogenism +PCO), and D (oligoovulation+absent PCO) were considered for PCOS. The homeostatic model assessment for ınsulin resistance (HOMA-IR) was used to evaluate IR. The Mann-Whitney U test was performed to study the difference between the groups. Results: The highest value of HOMA-IR was for the phenotype B group, and the lowest value was for the phenotype C group. However, the difference between the groups was not significant (p=0.221). Estradiol and free T4 were significantly higher in the phenotype A group (p≤0.001). Thyroid-stimulating hormone (TSH), prolactin, anti-mullerian hormone (AMH), fasting insulin, total testosterone, and red blood cell distribution width (RDW) were significantly higher in the phenotype B group (p≤0.001). Total cholesterol, high density lipoprotein (HDL), leukocyte, basophil, and monocyte were significantly higher in the phenotype C group (p≤0.001). Also, MPV values were significantly higher in the phenotype D group (p≤0.001). Conclusion: The results showed that the variables related to IR in phenotypes A and B of PCOS are higher than in other phenotypes.