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Many subtypes of acute lymphoblastic leukemia (ALL) are associated with specific chromosomal rearrangements. The complex translocation t(9;14;14), a variant of the translocation (14;14)(q11;q32), is a rare but recurrent chromosomal abnormality involving the immunoglobulin heavy-chain (IGH) and CCAAT enhancer-binding protein (CEBPE) genes in B-lineage ALL (B-ALL) and may represent a new B-ALL subgroup. We report here the case of a 5-year-old girl with B-ALL, positive for CD19, CD38 and HLA-DR. A direct technique and G-banding were used for chromosomal analysis and fluorescentin situ hybridization (FISH) with BAC probes was used to investigate a possible rearrangement of the IGH andCEBPE genes. The karyotype exhibit the chromosomal aberration 46,XX,del(9)(p21),t(14;14)(q11;q32). FISH with dual-color break-apartIGH-specific and CEPBE-specific bacterial artificial chromosome (BAC) probes showed a complex t(9;14;14) associated with a deletion of cyclin-dependent kinase inhibitor 2A (CDKN2A) and paired box gene 5 (PAX5) at 9p21-13 and duplication of the fusion gene IGH-CEBPE.

The emergency of the Covid 19 pandemic has led technology to seek solutions to the different problems caused by the disease. In the monitoring area, connected devices offer new possibilities to a rapid detection and intervention of the new cases. They allow remote diagnostic to infected patients with covid 19 symptoms. However, the heterogeneity of the platform requires applications' developers to develop specific solutions for each platform. In this paper, we propose a cross-platform application that permits developer to use one code to build applications in different platforms. The paper describes the architecture of the application by presenting its three parts: interface screens (UI), data manipulation and authentication implementation. Finally, we show selected screens of an android release as an example.